4-Nitrobenzeneethanol Chemical Properties

Melting point:

59-62 °C(lit.)

Boiling point:

177 °C16 mm Hg(lit.)

Density 

1.2917 (rough estimate)

refractive index 

1.5570 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol (Slightly)

form 

Solid

pka

14.57±0.10(Predicted)

color 

White to Light Brown

Water Solubility 

<0.01 g/100 mL at 18 ºC

BRN 

1866148

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.

CAS DataBase Reference

100-27-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneethanol, 4-nitro-(100-27-6)

EPA Substance Registry System

4-Nitrobenzeneethanol (100-27-6)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-36-40-36/37/38

Safety Statements 

22-24/25-26-36

WGK Germany 

3

RTECS 

SG8602000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29062990

MSDS

• Language:English Provider:2-(p-Nitrophenyl)ethanol
• Language:English Provider:SigmaAldrich

4-Nitrobenzeneethanol Usage And Synthesis

Chemical Properties

yellow to orange crystalline powder

Uses

4-Nitro-benzeneethanol is a useful synthetic intermediate. It can be used to synthesize N-phenylethylindole carboxamides as SAR study of allosteric modulators of CB1 receptor. It can also be used to prepare 2-aza-2''-deoxyinosine-containing oligodeoxyribonucleotide duplexes.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 2786, 1973 DOI: 10.1021/jo00956a011

General Description

Yellow needles (from aqueous methanol) or orange solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

SYMPTOMS: Structurally similar chemicals may cause methemoglobinemia.

Fire Hazard

Flash point data for 4-Nitrobenzeneethanol are not available; however, 4-Nitrobenzeneethanol is probably combustible.

4-Nitrobenzeneethanol(100-27-6)Related Product Information

• 4-Nitrobenzoic acid
• Ethyl acetate
• Ethanol
• 4-Nitrobenzyl alcohol
• Phenethyl alcohol
• 4-Nitrobenzaldehyde
• Sodium 3-nitrobenzenesulphonate
• BIS(2,4-DINITROPHENYL)ACETIC ACID ETHYL ESTER
• ETHYL 4-NITROPHENYLGLYOXYLATE
• 2,4-DINITROPHENYLACETIC ACID
• 4-NITROPHENYLACETIC ACID SODIUM SALT
• Ethyl 4-nitrophenylacetate
• Nitrobenzene
• 2-(4-NITROPHENYL)PROPIONIC ACID
• 1-(4-NITROPHENYL)GLYCEROL
• 4-NITROPHENYLSUCCINIC ACID
• Methyl p-nitrophenylacetate
• 4-Chloronitrobenzene