Propargyl-PEG3-NH2 CAS#: 932741-19-0

Propargyl-PEG3-NH2 Basic information

Product Name:

Propargyl-PEG3-NH2

Synonyms:

Ethanamine, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
Alkyne-PEG3-amine
2‐(2‐(2‐(prop‐2‐yn‐1‐yloxy)ethoxy)ethoxy)ethanamine
2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethan-1-amine
Propargyl-PEG3-NH2/Ethanamine, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
NH2-PEG3-Al
2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethanamine
3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)prop-1-yne

CAS:

932741-19-0

MF:

C9H17NO3

MW:

187.24

Product Categories:

peg

Mol File:

932741-19-0.mol

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Propargyl-PEG3-NH2 Chemical Properties

Boiling point:: 267.4±25.0 °C(Predicted)
Density: 1.019±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
solubility: Soluble in Water, DMSO, DCM, DMF
pka: 8.74±0.10(Predicted)
form: Liquid
color: Colorless to light yellow
Appearance: colorlessoryellowish liquid
InChI: InChI=1S/C9H17NO3/c1-2-4-11-6-8-13-9-7-12-5-3-10/h1H,3-10H2
InChIKey: MREICTHRFCQNJR-UHFFFAOYSA-N
SMILES: C(N)COCCOCCOCC#C

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Propargyl-PEG3-NH2 Usage And Synthesis

Description

Propargyl-PEG3-amine is a PEG linker that is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group reacts with azides in copper catalyzed azide-alkyne Click Chemistry.

Uses

Propargyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Propargyl-PEG3-NH2Supplier

Hangzhou HanLai Biochemical Technology Co., Ltd. Gold

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PharmaBlock Sciences (Nanjing),Inc.

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T&W GROUP

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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Email: et@chemextension.com

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