LEIUROTOXIN I
LEIUROTOXIN I Basic information
- Product Name:
- LEIUROTOXIN I
- Synonyms:
-
- LEIUROTOXIN I
- LEIUROTOXIN I (SCORPION, LEIURUS QUINQUESTRIATUS HEBRAEUS)
- LETX I
- LETX I SCORPION TOXIN
- H-ALA-PHE-CYS-ASN-LEU-ARG-MET-CYS-GLN-LEU-SER-CYS-ARG-SER-LEU-GLY-LEU-LEU-GLY-LYS-CYS-ILE-GLY-ASP-LYS-CYS-GLU-CYS-VAL-LYS-HIS-NH2
- H-ALA-PHE-CYS-ASN-LEU-ARG-MET-CYS-GLN-LEU-SER-CYS-ARG-SER-LEU-GLY-LEU-LEU-GLY-LYS-CYS-ILE-GLY-ASP-LYS-CYS-GLU-CYS-VAL-LYS-HIS-NH2, (DISULFIDE BONDS BETWEEN CYS3 AND CYS21/CYS8 AND CYS26/ CYS12 AND CYS28)
- ALA-PHE-CYS-ASN-LEU-ARG-MET-CYS-GLN-LEU-SER-CYS-ARG-SER-LEU-GLY-LEU-LEU-GLY-LYS-CYS-ILE-GLY-ASP-LYS-CYS-GLU-CYS-VAL-LYS-HIS-NH2
- SCYLLATOXIN
- CAS:
- 142948-19-4
- MF:
- C142H237N45O39S7
- MW:
- 3423.13
- Mol File:
- 142948-19-4.mol
LEIUROTOXIN I Chemical Properties
- Density
- 1.51±0.1 g/cm3(Predicted)
LEIUROTOXIN I Usage And Synthesis
Uses
Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1].
in vivo
Scyllatoxin (2 μM) increases basal Epi release, the nerve stimulation-induced Epi release and the exogenous acetylcholine (Ach)-induced catecholamine release by microdialysis technique to the left adrenal medulla of anesthetized adult male Wistar rats[2].
References
[1] Auguste P, et al. Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 1992 Jan 28;31(3):648-54. DOI:10.1021/bi00118a003
[2] Akiyama T, et al. Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla. Neurochem Int. 2010 Jan;56(2):263-9. DOI:10.1016/j.neuint.2009.10.010
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