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Vidarabine monophosphate

Basic information Safety Supplier Related

Vidarabine monophosphate Basic information

Product Name:
Vidarabine monophosphate
Synonyms:
  • 9H-Purin-6-amine,9-(5-O-phosphono-b-D-arabinofuranosyl)-
  • ARA-AMP
  • 9-BETA-D-ARABINOFURANOSYLADENINE-5'-MONOPHOSPHATE
  • 9-BETA-D-ARABINOFURANOSYL-ADENINE-5'-MONOPHOSPHORIC ACID
  • 9-BETA-D-ARABINOFURANOSYLADENINE MONOPHOSPHATE
  • 9-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE
  • ADENINE-9-BETA-D-ARABINOFURANOSIDE-5'-MONOPHOSPHATE
  • ADENINE-BETA-D-ARABINOFURANOSIDE-5'-PHOSPHATE
CAS:
29984-33-6
MF:
C10H14N5O7P
MW:
347.22
EINECS:
249-990-8
Product Categories:
  • 29984-33-6
Mol File:
29984-33-6.mol
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Vidarabine monophosphate Chemical Properties

Melting point:
213 °C
Boiling point:
798.5±70.0 °C(Predicted)
Density 
2.32±0.1 g/cm3(Predicted)
storage temp. 
Store at 0°C
form 
Powder
pka
1.86±0.10(Predicted)
color 
White to Off-white
Water Solubility 
Soluble in water at 4mg/ml
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Safety Information

Hazard Codes 
Xn,T,Xi
Risk Statements 
20/22-40-23/24/25-36/37/38
Safety Statements 
37/39-24/25-45-36/37/39-22-36-26
RIDADR 
2811
RTECS 
AU6204000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29400090
Toxicity
LD50 ipr-rat: 1700 mg/kg DRFUD4 4,547,79

MSDS

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Vidarabine monophosphate Usage And Synthesis

Description

Vidarabine monophosphate, chemical name: 9-(5-O-Phosphono-beta-D-arabinofuranosyl)adenine is an anti deoxyribonucleic acid virus drug. IVidarabine triphosphate directly inhibits DNA polymerase and also acts as a chain terminator in DNA replication. An adenosine monophosphate analog in which ribose is replaced by an arabinose moiety. It is the monophosphate ester of VIDARABINE with antiviral and possibly antineoplastic properties.

Chemical Properties

Crystalline

Uses

Antiviral.

Uses

Disrupts viral DNA synthesis. Competitive viral DNA polymerase inhibitor. Active against herpes simplex and varicella zoster viruses in vivo.

Application

Vidarabine monophosphate has broad-spectrum anti-virus effect and can inhibit a variety of DNA viruses. It is mainly used to treat chronic hepatitis B and other viral infections, such as herpes zoster, herpes simplex and genital herpes. It has quick effect and clear curative effect. It is a common drug for clinical anti-virus treatment.

Safety Profile

Moderately toxic byintraperitoneal route. When heated to decomposition itemits very toxic fumes of POx and NOx.

Vidarabine monophosphateSupplier

Hainan gourd Pharmaceutical Co., Ltd. Gold
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Hongene Biotech Corporation
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China DongFan Chemical Co.,LTD
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XiaoGan ShenYuan ChemPharm co,ltd
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