Disodium clodronate tetrahydrate Chemical Properties

storage temp. 

2-8°C

solubility 

Soluble in Water (up to at least 10 mg/ml)

form 

White solid

color 

White

Merck 

14,2371

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.

InChIKey

XWHPUCFOTRBMGS-UHFFFAOYSA-L

Safety Information

RTECS 

SZ7640700

HS Code 

2931.39.0030

Disodium clodronate tetrahydrate Usage And Synthesis

Description

Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC₅₀ = 1.34 μM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.

Uses

Disodium Clodronate Tetrahydrate is a bisphosphonate bone growth regulator.

Definition

ChEBI: The tetrahydrate of the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions nd bone pain associated with skeletal metastases.

References

1) Plosker and Goa (1994), Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease; Drugs 47 945 2) Lehenkari et al. (2002), Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite; Mol.Pharmacol. 61 1255

Disodium clodronate tetrahydrate(88416-50-6)Related Product Information

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