3,5-Lutidine Chemical Properties

Melting point:

-9 °C (lit.)

Boiling point:

169-170 °C (lit.)

Density 

0.939 g/mL at 25 °C (lit.)

vapor pressure 

1.5 mm Hg ( 20 °C)

refractive index 

n20/D 1.504(lit.)

Flash point:

128 °F

storage temp. 

2-8°C

form 

Liquid

pka

6.15(at 25℃)

color 

Clear yellow

Water Solubility 

33 g/L (20 ºC)

Sensitive 

Hygroscopic

BRN 

105682

InChIKey

HWWYDZCSSYKIAD-UHFFFAOYSA-N

LogP

1.780

CAS DataBase Reference

591-22-0(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 3,5-dimethyl-(591-22-0)

EPA Substance Registry System

3,5-Dimethylpyridine (591-22-0)

Safety Information

Hazard Codes 

Xn,F,Xi,T

Risk Statements 

10-20/21/22-36/37/38-41-34-23/25-21

Safety Statements 

16-26-36-36/37-45-36/37/39

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

F 

8

Hazard Note 

Irritant/Flammable

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29333999

MSDS

• Language:English Provider:3,5-Dimethylpyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,5-Lutidine Usage And Synthesis

Chemical Properties

CLEAR YELLOW LIQUID

Uses

3,5-Lutidine is a reactant used in the synthesis of phthalazine and pyrazine compounds, as well as other pharmaceuticals.

Synthesis Reference(s)

Synthesis, p. 573, 1994 DOI: 10.1055/s-1994-25526

Flammability and Explosibility

Flammable

Purification Methods

Dry 3,5-lutidine with sodium and fractionally distil it through a Todd column (p 11) packed with glass helices. Dissolve (100mL) in dilute HCl (1:4) and steam distil this until 1L of distillate is collected. Excess conc NaOH is added to the residue which is again steam distilled. The base is extracted from the distillate, using diethyl ether. The extract is dried over K2CO3, and distilled. It is then fractionally crystallised by partial freezing. The hydrochloride has m 229o(sublimes at 190-231o), and the picrate has m 242-243o(dec, from H2O), 249-250o(dec, from AcOH). [Beilstein 20 II 161, 20 III/IV 2788, 20/6 V 60.]

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