Calcipotriene Chemical Properties

Melting point:

166-168°C

storage temp. 

Desiccate at -20°C

solubility 

DMSO: soluble15mg/mL, clear

form 

powder

InChIKey

LWQQLNNNIPYSNX-HCHVWAPNSA-N

CAS DataBase Reference

112965-21-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HS Code 

2906195000

MSDS

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Calcipotriene Usage And Synthesis

Description

Calcipotriol is a topical vitaminD₃ derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D₃ receptors in the skin keratinocytes, producing an elevation in cell differentiation and a reduction in cell proliferation. Although its efficacy is comparable to calcitriol, calcipotriol exhibits at least 100 times less effect on calcium metabolism in rats.

Chemical Properties

White Crystalline Solid

Originator

Leo Denmark (Denmark)

Uses

An antipsoriatic. A vitamin D3 analogue with low calcemic activity

Uses

antipsoriatic;viamin D receptor (VDR) affinity

Uses

A labelled antipsoriatic. A vitamin D3 analogue with low calcemic activity.

Indications

Calcipotriene (Dovonex), a synthetic vitamin D3 derivative, is indicated for the treatment of moderate plaque psoriasis. Its mechanism of action is unknown, although it competes for calcitriol receptors on keratinocytes and normalizes differentiation. It also has a variety of immunomodulatory effects in the skin. Although the drug can cause local irritation, the most serious toxicities are hypercalciuria and hypercalcemia, which are usually reversible.

brand name

Dovonex (Leo);Daivonex.

Biological Activity

Vitamin D 3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

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