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Calcipotriene

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Calcipotriene Basic information

Product Name:
Calcipotriene
Synonyms:
  • 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1α,3β,5Z,7E,22E,24S)-
  • Calciptriol
  • Daivobet
  • Daivonex
  • calcipotriol anhydre ep5.3
  • (1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
  • Calcipotriene
  • CALCIPOTRIOL - EP
CAS:
112965-21-6
MF:
C27H40O3
MW:
412.6
EINECS:
601-218-4
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • -
  • Isotope Labelled Compounds
Mol File:
112965-21-6.mol
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Calcipotriene Chemical Properties

Melting point:
166-168°C
storage temp. 
Desiccate at -20°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
InChIKey
LWQQLNNNIPYSNX-HCHVWAPNSA-N
CAS DataBase Reference
112965-21-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2906195000

MSDS

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Calcipotriene Usage And Synthesis

Description

Calcipotriol is a topical vitaminD3 derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D3 receptors in the skin keratinocytes, producing an elevation in cell differentiation and a reduction in cell proliferation. Although its efficacy is comparable to calcitriol, calcipotriol exhibits at least 100 times less effect on calcium metabolism in rats.

Chemical Properties

White Crystalline Solid

Originator

Leo Denmark (Denmark)

Uses

An antipsoriatic. A vitamin D3 analogue with low calcemic activity

Uses

antipsoriatic;viamin D receptor (VDR) affinity

Uses

A labelled antipsoriatic. A vitamin D3 analogue with low calcemic activity.

Indications

Calcipotriene (Dovonex), a synthetic vitamin D3 derivative, is indicated for the treatment of moderate plaque psoriasis. Its mechanism of action is unknown, although it competes for calcitriol receptors on keratinocytes and normalizes differentiation. It also has a variety of immunomodulatory effects in the skin. Although the drug can cause local irritation, the most serious toxicities are hypercalciuria and hypercalcemia, which are usually reversible.

brand name

Dovonex (Leo);Daivonex.

Biological Activity

Vitamin D 3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Calcipotriene Preparation Products And Raw materials

Raw materials

CalcipotrieneSupplier

Chemvon Biotechnology Co., Ltd Gold
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+86-21-50790412
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marketing@chemvon.com
Pure Chemistry Scientific Inc. Gold
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001-857-928-2050 or 1-888-588-9418
Email
sales@chemreagents.com
Hydragon Pharma Ltd Gold
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+86(21)5021-5258, 5021-8972
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market@hypharma.com
Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
J & K SCIENTIFIC LTD.
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400-666-7788 +86-10-82848833
Email
jkinfo@jkchemical.com;market6@jkchemical.com