Calcipotriene
- Product Name:Calcipotriene
- Synonyms: 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1α,3β,5Z,7E,22E,24S)- Calciptriol Daivobet Daivonex calcipotriol anhydre ep5.3 (1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol Calcipotriene CALCIPOTRIOL - EP
- CAS:112965-21-6
- MF:C27H40O3
- MW:412.6
- EINECS:601-218-4
- Product Categories: Intermediates & Fine Chemicals Pharmaceuticals - Isotope Labelled Compounds
- Mol File:112965-21-6.mol
-
Calcipotriene Chemical Properties
- Melting point:166-168°C
- storage temp. Desiccate at -20°C
- solubility DMSO: soluble15mg/mL, clear
- form powder
- InChIKeyLWQQLNNNIPYSNX-HCHVWAPNSA-N
- CAS DataBase Reference112965-21-6(CAS DataBase Reference)
- Language:EnglishProvider:Calcipotriene
Calcipotriene Usage And Synthesis
- DescriptionCalcipotriol is a topical vitaminD3 derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D3 receptors in the skin keratinocytes, producing an elevation in cell differentiation and a reduction in cell proliferation. Although its efficacy is comparable to calcitriol, calcipotriol exhibits at least 100 times less effect on calcium metabolism in rats.
- Chemical PropertiesWhite Crystalline Solid
- OriginatorLeo Denmark (Denmark)
- UsesAn antipsoriatic. A vitamin D3 analogue with low calcemic activity
- Usesantipsoriatic;viamin D receptor (VDR) affinity
- UsesA labelled antipsoriatic. A vitamin D3 analogue with low calcemic activity.
- IndicationsCalcipotriene (Dovonex), a synthetic vitamin D3 derivative, is indicated for the treatment of moderate plaque psoriasis. Its mechanism of action is unknown, although it competes for calcitriol receptors on keratinocytes and normalizes differentiation. It also has a variety of immunomodulatory effects in the skin. Although the drug can cause local irritation, the most serious toxicities are hypercalciuria and hypercalcemia, which are usually reversible.
- brand nameDovonex (Leo);Daivonex.
- Biological ActivityVitamin D 3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
Calcipotriene Preparation Products And Raw materials
- (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one CALCIPOTRIOL MONOHYDRATE (1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldiMethylsilyl)oxy)-2-Methylenecyclohexylidene)ethylidene)-7a-Methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol Calcipotriene Calcipotriene Tetrapropylammonium hydroxide Allyl glycidyl ether Allyl chloride Propylthiouracil Cocoyl amide propyldimethyl glycine CHLOROPHOSPHONAZO III Allyl bromide N,N-Diisopropylethylamine
CalcipotrieneSupplierMore
- Company Name:Chemvon Biotechnology Co., Ltd Gold
- Tel:+86-21-50790412
- Email:marketing@chemvon.com
- Company Name:Pure Chemistry Scientific Inc. Gold
- Tel:001-857-928-2050 or 1-888-588-9418
- Email:sales@chemreagents.com
- Company Name:Hydragon Pharma Ltd Gold
- Tel:+86(21)5021-5258, 5021-8972
- Email:market@hypharma.com
- Company Name:Wuhan Biocar Bio-Pharm Co., Ltd. Gold
- Tel:17717864505
- Email:11179779@qq.com
- Company Name:Shanghai Boyle Chemical Co., Ltd.
- Tel:
- Email:sales@boylechem.com