5-Hydroxyisophthalic acid Chemical Properties

Melting point:

298-302 °C (lit.)

Boiling point:

235.5°C (rough estimate)

Density 

1.3293 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.4330 (estimate)

storage temp. 

Store below +30°C.

solubility 

0.6g/l

form 

Powder

pka

3.41±0.10(Predicted)

color 

White to slightly yellow

PH

<7 (H2O, 20℃)

Water Solubility 

0.6g/L(15 ºC)

BRN 

2693561

Dissociation constant

0-0 at 23℃

CAS DataBase Reference

618-83-7(CAS DataBase Reference)

EPA Substance Registry System

5-Hydoxyisophthalic acid (618-83-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-24/25-36

WGK Germany 

2

RTECS 

CZ4280000

TSCA 

Yes

HS Code 

29182990

MSDS

• Language:English Provider:5-HIPA
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Hydroxyisophthalic acid Usage And Synthesis

Chemical Properties

white to slightly yellow powder

Uses

5-Hydroxyisophthalic Acid is used as a reagent in the synthesis of silver carboxylate metal organic framework (MOF) complexes. 5-Hydroxyisophthalic Acid is also used as the starting material in the synthesis of N,NтАЩ-Bis(2,3-dihydroxypropyl)-5-[(N-(2-hydroxyethyl)carbamoyl)methoxy]-2,4,6-triiodoisophthalamide (B426310); a compound related to Ioversol( I737000) which is a nonionic, low osmolality, radiographic contrast agent.

General Description

The hydrothermal reaction of 5-hydroxyisophthalic acid, Co(II)/Cu(II) and dipyridophenazine, that forms two 3D chiral coordination polymers, was studied.

Synthesis

The general procedure for the synthesis of 5-hydroxyisophthalic acid from dimethyl 5-hydroxyisophthalate was as follows: dimethyl 5-hydroxyisophthalate (40 g, 19.03 mmol) was dissolved in THF (10 mL), followed by the addition of aqueous lithium hydroxide (20 mL, 2 M). The reaction mixture was stirred at 40 °C overnight. Upon completion of the reaction, THF was removed by distillation under reduced pressure. the pH of the remaining aqueous solution was adjusted to about 2 with 6N hydrochloric acid to precipitate the product. The precipitated 5-hydroxyisophthalic acid was collected by filtration and dried in a vacuum oven to give 20 g of white solid product in 58% yield.

References

[1] Patent: WO2010/78449, 2010, A2. Location in patent: Page/Page column 317

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