4-Cloromethyl-5-methyl-1,3-dioxol-2-one
4-Cloromethyl-5-methyl-1,3-dioxol-2-one Basic information
- Product Name:
- 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
- Synonyms:
-
- DMDO-CL
- 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
- Olmesartan Impurity 57
- 4-CloroMethyl-5-Methyl-1,3-dioxol-2-one (DMDO-Cl)
- OlMesartan IMpurity (4-(ChloroMethyl)-5-Methyl-1,3-Dioxol-2-one)
- 4- chloroMethyl-5- Methyl-1,3- two oxygenheterocyclicpentadiene-2- ketone
- -5--1,3- two4-chloroMethylMethylcyclopentene-2- ketoneheterocyclic oxygen
- 4-ChloroMethyl-5-Methyl-l,3-dioxocyclopenten-2–one
- CAS:
- 80841-78-7
- MF:
- C5H5ClO3
- MW:
- 148.54
- EINECS:
- 617-178-6
- Product Categories:
-
- Carbonates
- Carbonyl Compounds
- Chemical intermediate for Olmesartane
- INTERMEDIATESOF
- Organic Building Blocks
- Pharmaceutical Intermediates
- Mol File:
- 80841-78-7.mol
4-Cloromethyl-5-methyl-1,3-dioxol-2-one Chemical Properties
- Boiling point:
- >90℃/2mm
- Density
- 1.362±0.06 g/cm3(Predicted)
- refractive index
- 1.4760-1.4820
- Flash point:
- 129 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- liquid
- color
- Colorless to Light yellow to Light orange
- Specific Gravity
- 1.36
- BRN
- 4798926
- InChI
- InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3
- InChIKey
- QCLFSYYUWPUWQR-UHFFFAOYSA-N
- SMILES
- CC1=C(OC(=O)O1)CCl
- CAS DataBase Reference
- 80841-78-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- HS Code
- 29329990
4-Cloromethyl-5-methyl-1,3-dioxol-2-one Usage And Synthesis
Description
4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide.
Chemical Properties
Colorless to Light yellow to Light orange clear liquid or Pale Yellow Oil.
Uses
4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.
Preparation
4,5-dimethyl-1,3-dioxole-2-ketone (DMDO) is used as raw material, taking sulfonic acid chloride as a chlorinating agent. The reaction is reat under the effect of a catalyzer in organic solvent and reacts for 1-5 hours to obtain target product 4-Cloromethyl-5-methyl-1,3-dioxol-2-one.
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4-Cloromethyl-5-methyl-1,3-dioxol-2-one(80841-78-7)Related Product Information
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