TETRAHYDROALSTONINE
TETRAHYDROALSTONINE Basic information
- Product Name:
- TETRAHYDROALSTONINE
- Synonyms:
-
- ALSTONINE
- 20-alpha)-lph
- 3,4,5,6-tetrahydro-alstonin
- TETRAHYDROALSTONINE
- methyl (19alpha,20alpha)-16,17-didehydro-19-methyloxayohimban-16-carboxylate
- TETRAHYDROALSTONINE(RG)
- (20α)-16,17-Didehydro-19α-methyl-18-oxayohimban-16-carboxylic acid methyl ester
- 3α,4,5,6-Tetrahydroalstonine
- CAS:
- 6474-90-4
- MF:
- C21H24N2O3
- MW:
- 352.43
- EINECS:
- 229-331-0
- Product Categories:
-
- Alkaloids
- Miscellaneous Natural Products
- Mol File:
- 6474-90-4.mol
TETRAHYDROALSTONINE Chemical Properties
- Melting point:
- 227°C
- Boiling point:
- 524.0±50.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Solid
- pka
- 18.03±0.60(Predicted)
- color
- Off-white to light yellow
- LogP
- 2.880 (est)
TETRAHYDROALSTONINE Usage And Synthesis
Uses
Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].
Definition
ChEBI: Tetrahydroalstonine is a heteropentacyclic compound that is (20alpha)-16,17-didehydro-18-oxayohimban which is substituted at position 16 by a methoxycarbonyl group and at position 19 by a methyl group. It is a metabolite found in several plant species. It has a role as a plant metabolite. It is a yohimban alkaloid, an organic heteropentacyclic compound and a methyl ester. It is a conjugate base of a tetrahydroalstonine(1+).
target
Adrenergic Receptor
References
[1] Malik S, et al. Tetrahydroalstonine?from Fruits of Rhazya stricta. Planta Med.?1984 Jun;50(3):283. DOI:10.1055/s-2007-969707
[2] Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5.https://www.ncbi.nlm.nih.gov/pubmed/6099269 DOI:10.1016/0014-2999(84)90698-8
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