URIDINE 5'-TRIPHOSPHATE TRIS SALT Chemical Properties

storage temp. 

-20°C

solubility 

H2O: soluble50mg/mL, clear, colorless

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-36/37/38

Safety Statements 

22-26-36-45

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

URIDINE 5'-TRIPHOSPHATE TRIS SALT Usage And Synthesis

Uses

Uridine 5''-Triphosphate Tris Salt is a polyphosphate analogue of the nucleoside Uridine used in the preparation of potent and selective agonists at the G-protein-coupled P2Y receptors.

Uses

Uridine 5′-triphosphate tris salt has been used:

• to investigate its activation potential on the purinergic?P2Y2 Receptor in THP1 monocytes
• as a component of non-radioactive nucleoside triphosphate solution used in in vitro RNA polymerase assay
• as a P2Y2 agonist in human embryonic kidney cells (HEK293T) in dynamic mass redistribution (DMR) assays

Biochem/physiol Actions

Uridine 5′-triphosphate (UTP) is synthesized from uridine 5′-diphosphate (UDP) in the presence of the enzyme nucleoside diphosphate kinase (NDPK). Plant cells have high uridine as UTP. UTP on amination results in the generation of CTP and is catalysed by enzyme CTP synthetase. UTP acts on the purinergic?(P2Y2) receptor and mediates smooth muscle cells (SMCs) mitogenic activation. It also modulates osteopontin expression in SMCs. UTP is a sputum inducer and a promising candidate for assessing the inflammation in respiratory airway.

URIDINE 5'-TRIPHOSPHATE TRIS SALT(108321-53-5)Related Product Information

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