TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID Chemical Properties

Melting point:

111-112℃

Boiling point:

407.2±38.0 °C(Predicted)

Density 

1.182±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Solid

pka

3.51±0.10(Predicted)

color 

White to off-white

optical activity

Consistent with structure

CAS DataBase Reference

3601-66-9(CAS DataBase Reference)

TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID Usage And Synthesis

Uses

Boc-DL-Phg-OH is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1].

Synthesis

General procedure for the synthesis of BOC-L-phenylglycine from di-tert-butyl dicarbonate and 2-amino-2-phenylacetic acid: DL-2-phenylglycine (5.0 g, 33 mmol) was dissolved in 1 N NaOH solution (132 mL). Subsequently, di-tert-butyl dicarbonate (19.0 mL, 82.7 mmol) was added and the reaction mixture was stirred at room temperature until the reaction was complete. N-tert-butoxycarbonyl-DL-phenylglycine was isolated as a white solid (7.61 g, 92% yield) by appropriate post-processing steps.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID(3601-66-9)Related Product Information

• TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID
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• (S)-TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID
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• BOC-2,4-DINITRO-DL-PHENYLGLYCINE
• BOC-4-HYDROXY-D-PHENYLGLYCINE
• BOC-PHG-OSU
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