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NISTOSE

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NISTOSE Basic information

Product Name:
NISTOSE
Synonyms:
  • 1-O-(1-O-β-D-Fructofuranosyl-β-D-fructofuranosyl)-β-D-fructofuranosyl α-D-glucopyranoside
  • 2-O-(2-O-α-D-Glucopyranosyl-1-deoxy-β-D-fructofuranose-1-yl)-1-deoxy-β-D-fructofuranose-1-yl β-D-fructofuranoside
  • (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
  • (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-3,4-dihydroxy-2,5-dimethylol-tetrahydrofuran-2-yl]oxymethyl]-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]oxymethyl]-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-6-methylol-tetrahydropyran-3,4,5-triol
  • Nystose,β-D-Fruf-(2->1)-β-D-Fruf-(2->1)-β-D-Fruf-(2<-->1)-α-D-Glup
  • Nystose ,98%
  • Fungitetraose Nystose
  • 1)-b-D-fructofuranosyl
CAS:
13133-07-8
MF:
C24H42O21
MW:
666.58
Product Categories:
  • Basic Sugars (Mono & Oligosaccharides)
  • Biochemistry
  • Sugars
  • Tetrasaccharides
Mol File:
13133-07-8.mol
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NISTOSE Chemical Properties

Melting point:
130-133℃
Boiling point:
1075.7±65.0 °C(Predicted)
Density 
1.84±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
10 ° (C=4, H2O)
storage temp. 
Sealed in dry,2-8°C
solubility 
H2O : 300 mg/mL (450.06 mM; Need ultrasonic and warming)
form 
Solid
pka
12.76±0.70(Predicted)
color 
White to off-white
BRN 
6171779
InChIKey
FLDFNEBHEXLZRX-DLQNOBSRSA-N
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29400090

MSDS

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NISTOSE Usage And Synthesis

Chemical Properties

White crystal

Uses

Fungitetraose is a part of the sugar mixture of Neosugar, sweetner.

Definition

ChEBI: Nystose is an oligosaccharide.

Synthesis

25101-99-9

13133-07-8

The general procedure for the synthesis of the target compound from the compound (CAS: 25101-99-9) was as follows: 100 mg of Hex4perAc was dissolved in 5 mL of methanol (MeOH), followed by the addition of 18 mg (0.3 eq.) of sodium methanolate (CH3ONa). After stirring the reaction mixture for 2.5 h at room temperature, Dowex 50Wx2 [H+] resin was added to neutralize the reaction solution. The resin was removed by filtration and the solvent was removed by distillation under reduced pressure. The residue was dissolved in water (H2O) and desalted using a Bio-Gel P-2 gel (10 mL). Finally, a white solid product (57 mg) was obtained by freeze-drying.

in vivo

Nystose (100 mg/kg, po for 14 days) enhances the intestinal IgA secretion and modulates systemic immune responses in BALB/c mouse models[2].
Nystose (40-160 mg/kg, po for 8 weeks) improves the bone density and bone microstructure in mouse models[3].

Animal Model:BALB/c mouse models[2]
Dosage:100 mg/kg
Administration:po for 14 days
Result:Inhibited the secretion of IL-2, IFN-γ, IL-12 and IL-4 by splenocytes.
Animal Model:ICR mouse models[3]
Dosage:40-160 mg/kg
Administration:po for 8 weeks
Result:Improved the bone density and bone microstructure.

target

IFN-γ | IL Receptor

References

[1] Patent: CN103638162, 2016, B. Location in patent: Paragraph 0056
[2] Molecules, 2018, vol. 23, # 2,

NISTOSESupplier

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021-021-58432009 400-005-6266
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