REVEROMYCIN A
REVEROMYCIN A Basic information
- Product Name:
- REVEROMYCIN A
- Synonyms:
-
- REVEROMYCIN A
- ZESGNAJSBDILTB-OXVOKJAASA-N
- Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
- CAS:
- 134615-37-5
- MF:
- C36H52O11
- MW:
- 660.79
- Product Categories:
-
- Epidermal Growth Factor Receptor (EGFR)Antibiotics
- Interferes with Protein Synthesis
- Antibiotics
- Antibiotics A to
- Antibiotics by Application
- Antibiotics N-SAntibiotics
- Antineoplastic and Immunosuppressive AntibioticsReceptor Tyrosine Kinase Biology
- AntifungalAntibiotics
- Mechanism of Action
- Receptor Tyrosine Kinase Inhibitors
- Spectrum of Activity
- Mol File:
- 134615-37-5.mol
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REVEROMYCIN A Chemical Properties
- Boiling point:
- 849.0±65.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMF: soluble
- form
- solid
- pka
- 4.36±0.17(Predicted)
- color
- tan
MSDS
- Language:English Provider:SigmaAldrich
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REVEROMYCIN A Usage And Synthesis
Uses
Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of EGF. Reveromycin A is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behaviour against human cell lines KB and K562, as well as potent antifungal activity. More recently it has been shown to induce apoptosis in osteoclasts thus inhibiting bone resorption.
Uses
Reveromycin A is a spiroketal antibiotic inhibitor of EGF mitogenic activity. Inhibits the signal transduction of the epidermal growth factor. May be used
REVEROMYCIN ASupplier
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
Alfa Chemistry
- Tel
- 1-516-6625404
- support@alfa-chemistry.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
Lynnchem
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
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REVEROMYCIN A(134615-37-5)Related Product Information
- L-MIMOSINE
- VERRUCULOGEN
- Vinblastine sulfate
- S-Trityl-L-cysteine
- Morin hydrate
- Tangeretin
- MALVIDIN CHLORIDE
- TRYPROSTATIN A
- (E,E)-2,4-Dodecadienal
- FEMA 3766
- 1,1-DI(2-METHYLBUTOXY)ETHANE
- REVEROMYCIN A
- ACETIC ACID 2-METHYL-4-PENTEN-2-YL ESTER
- REVEROMYCIN D
- REVEROMYCIN C
- REVEROMYCIN B
- (-)-Reveromycin B, Synthetic
- (-)-REVEROMYCIN B