4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Basic information
- Product Name:
- 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
- Synonyms:
-
- RARECHEM AL BO 1323
- 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
- 4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID
- 4'-OCTYL-[1,1'-BIPHENYL]-4-CARBOXYLIC ACID
- 4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID
- 4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID
- 8BCA
- AC 55649
- CAS:
- 59662-49-6
- MF:
- C21H26O2
- MW:
- 310.43
- Product Categories:
-
- Biphenyl & Diphenyl ether
- Mol File:
- 59662-49-6.mol
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties
- Melting point:
- 148-152 °C(Solv: dichloromethane (75-09-2))
- Boiling point:
- 462.0±34.0 °C(Predicted)
- Density
- 1.037±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: >7mg/mL
- form
- solid
- pka
- 4.23±0.10(Predicted)
- color
- White to off-white
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Usage And Synthesis
Uses
AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).
Definition
ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.
Biological Activity
Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Biochem/physiol Actions
AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACIDSupplier
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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID(59662-49-6)Related Product Information
- 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
- 4-N-HEPTYLBIPHENYL
- 4-(4-ETHYLPHENYL)BENZOIC ACID
- 4-(4-n-Pentylphenyl)benzoic acid
- 4-N-HEXYLBIPHENYL-4'-CARBOXYLIC ACID
- 4'-Methylbiphenyl-4-carbaldehyde
- 4-Hexylbiphenyl
- 4-(4-N-BUTYLPHENYL)BENZOIC ACID
- 4-Biphenylcarboxylic acid
- 4-(4-N-PROPYLPHENYL)BENZOIC ACID
- 4-N-OCTYLBIPHENYL
- 4-(4'-N-HEPTYLPHENYL)BENZOIC ACID
- 4-(4-N-BUTYLPHENYL)BENZALDEHYDE
- 4-(4-N-PROPYLPHENYL)BENZALDEHYDE
- 4'-METHYLBIPHENYL-4-CARBOXYLIC ACID
- 4'-ETHYLBIPHENYL-4-CARBOXALDEHYDE
- 4-methyl-4'-pentyl-1,1'-biphenyl
- (4'-METHYLBIPHENYL-4-YL)-METHANOL