4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties

Melting point:

148-152 °C(Solv: dichloromethane (75-09-2))

Boiling point:

462.0±34.0 °C(Predicted)

Density 

1.037±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

DMSO: >7mg/mL

form 

solid

pka

4.23±0.10(Predicted)

Safety Information

WGK Germany 

3

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Usage And Synthesis

Uses

AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).

Definition

ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.

Biological Activity

Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.

Biochem/physiol Actions

AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID(59662-49-6)Related Product Information

• 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
• 4-N-HEPTYLBIPHENYL
• 4-(4-ETHYLPHENYL)BENZOIC ACID
• 4-(4-n-Pentylphenyl)benzoic acid
• 4-N-HEXYLBIPHENYL-4'-CARBOXYLIC ACID
• 4'-Methylbiphenyl-4-carbaldehyde
• 4-Hexylbiphenyl
• 4-(4-N-BUTYLPHENYL)BENZOIC ACID
• 4-Biphenylcarboxylic acid
• 4-(4-N-PROPYLPHENYL)BENZOIC ACID
• 4-N-OCTYLBIPHENYL
• 4-(4'-N-HEPTYLPHENYL)BENZOIC ACID
• 4-(4-N-BUTYLPHENYL)BENZALDEHYDE
• 4-(4-N-PROPYLPHENYL)BENZALDEHYDE
• 4'-METHYLBIPHENYL-4-CARBOXYLIC ACID
• 4'-ETHYLBIPHENYL-4-CARBOXALDEHYDE
• 4-methyl-4'-pentyl-1,1'-biphenyl
• (4'-METHYLBIPHENYL-4-YL)-METHANOL