Abacavir Chemical Properties

Boiling point:

636.0±65.0 °C(Predicted)

Density 

1.70±0.1 g/cm3(Predicted)

pka

14.86±0.10(Predicted)

Abacavir Usage And Synthesis

Uses

(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol (Abacavir EP Impurity D) is an impurity of Abacavir A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Abacavir(783292-37-5)Related Product Information

• Lamivudine
• Abacavir Carboxylate
• Abacavir-d4
• Abacavir
• Abacavir 5’-Phosphate
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)-
• trans-Abacavir Hydrochloride
• Abacavir
• 2,6-Diaminopurine
• 6-aminocarbovir
• (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol
• (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
• Abacavir Related CoMpound D
• Abacavir
• 2-Amino-6-cyclopropylamino-9H-purine
• Abacavir sulfate