Fmoc-N-amido-PEG24-acid CAS#: 2170484-59-8

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Fmoc-N-amido-PEG24-acid

Basic information Safety Supplier Related

Fmoc-N-amido-PEG24-acid Basic information

Product Name:

Fmoc-N-amido-PEG24-acid

Synonyms:

CAS_2170484-59-8
(Fmoc-amino)-PEG24-C2-Carboxylic Acid
Fmoc-N-PEG24-acid
5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74-Tetracosaoxa-2-azaheptaheptacontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester
1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76-pentacosaoxa-4-azanonaheptacontan-79-oic acid
FmocNH-PEG24-CH2CH2COOH/5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74-Tetracosaoxa-2-azaheptaheptacontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester
Fmoc-PEG24-propionic acid
Fmoc-NH-PEG

CAS:

2170484-59-8

MF:

C66H113NO28

MW:

1368.59

Mol File:

2170484-59-8.mol

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Fmoc-N-amido-PEG24-acid Chemical Properties

Boiling point:: 1108.7±65.0 °C(Predicted)
Density: 1.152±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, sealed storage, away from moisture
form: powder
pka: 4.28±0.10(Predicted)
color: White
InChIKey: NFOMZHGRFWXDGH-UHFFFAOYSA-N
SMILES: C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

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Safety Information

HS Code: 3822000000

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Fmoc-N-amido-PEG24-acid Usage And Synthesis

Description

Fmoc-N-amido-PEG24-acid contains an Fmoc-protected amine and a terminal carboxylic acid. The PEG spacer increases the aqueous solubility of the resulting compound. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid readily reacts with primary and secondary amine under EDC, DCC, HATU or other amide coupling conditions to form a stable amide bond.

Uses

Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Fmoc-N-amido-PEG24-acidSupplier

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