LOXO-292
LOXO-292 Basic information
- Product Name:
- LOXO-292
- Synonyms:
-
- RET-IN-1
- Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[5-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-2-pyrazinyl]-6-[(2R)-2-morpholinylmethoxy]-
- RET IN 1,RETIN1
- selpercatinib(LOX0292)
- CAS:
- 2222755-14-6
- MF:
- C29H31N9O3
- MW:
- 553.61
- Mol File:
- 2222755-14-6.mol
More
Less
LOXO-292 Chemical Properties
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
- solubility
- Soluble in DMSO
- pka
- 8.23±0.40(Predicted)
- form
- solid
- InChIKey
- GTQISTQEBXXLPC-UBVWURDFSA-N
- SMILES
- C12=C(C#N)C=NN1C=C(OC[C@@H]1OCCNC1)C=C2C1=NC=C(N2CC3CC(N3CC3=CC=C(OC)N=C3)C2)N=C1
More
Less
LOXO-292 Usage And Synthesis
Uses
Serpatinib (LOXO-292) is a potent, orally administered, highly selective transfection rearrangement (RET) kinase inhibitor used to treat cancer patients with RET abnormalities. The RET gene is a proto-oncogene that undergoes rearrangement during transfection, hence its name. This gene encodes a cell membrane receptor tyrosine kinase, and its abnormalities are a rare driver of many types of tumors.
Description
RET-IN-1 is an oral and selective investigational drug in clinical development for the treatment of patients with cancers that harbor abnormalities in the rearranged during transfection (RET) kinase.
LOXO-292Supplier
Liuyang huarui material technology co., ltd. Gold
- Tel
- 13467605171
- 2580432242@qq.com
Shanghai Hope Chem Co., Ltd.，
- Tel
- +21-18501659228 18501659228
- info@hope-chem.com
Beijing Yisiyan Technology Research Center
- Tel
- 010-56645598 13366904824
- bjkaida@163.com
Shanghai YuanQi Biotechnology Co., Ltd.
- Tel
- +86-2332782371 +86-18120098618
- sales@adobechem.com
Shanghai Send Pharmaceutical Technology Co., Ltd.
- Tel
- 021-58088081 Q2635253576
- hailey@shsendpharm.com
More
Less