Trifluoro-p-tolunitrile Chemical Properties

Melting point:

39-41 °C(lit.)

Boiling point:

80-81 °C20 mm Hg(lit.)

Density 

1.278 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.4583(lit.)

Flash point:

161 °F

storage temp. 

Sealed in dry,Room Temperature

Water Solubility 

Insoluble in water

solubility 

soluble in Chloroform, Methanol

form 

powder to lump to clear liquid

Specific Gravity

1.278

color 

White or Colorless to Light yellow

Sensitive 

Lachrymatory

BRN 

2046478

InChIKey

DRNJIKRLQJRKMM-UHFFFAOYSA-N

CAS DataBase Reference

455-18-5(CAS DataBase Reference)

NIST Chemistry Reference

4-Trifluoromethylbenzoic acid nitrile(455-18-5)

EPA Substance Registry System

Benzonitrile, 4-(trifluoromethyl)- (455-18-5)

Safety Information

Hazard Codes 

Xn,F

Risk Statements 

20/21/22-11

Safety Statements 

36/37-45-36

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

Hazard Note 

Lachrymatory

TSCA 

T

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269095

MSDS

• Language:English Provider:4-(Trifluoromethyl)benzonitrile
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Trifluoro-p-tolunitrile Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.

General Description

4-(Trifluoromethyl)benzonitrile is a key intermediate in the synthesis of fluvoxamine. It participates in nickel-catalyzed arylcyanation reaction of 4-octyne.

Trifluoro-p-tolunitrile(455-18-5)Related Product Information

• 2-(Trifluoromethyl)benzoic acid
• 4-Trifluoromethylphenylboronic acid
• 4-Trifluoromethylphenol
• 4-(Trifluoromethylthio)phenol
• Benzonitrile
• 3-(Trifluoromethyl)benzaldehyde
• 4-(Trifluoromethyl)benzene-1-sulfonyl chloride
• p-Tolunitrile
• 3-Aminobenzotrifluoride
• Trifluoromethanesulfonic acid
• 4'-(Trifluoromethyl)acetophenone
• 2-(Trifluoromethyl)benzaldehyde
• alpha,alpha,alpha-Trifluoro-o-toluoyl chloride
• 4-(TRIFLUOROMETHYL)PHENYLACETONITRILE
• 4-Nitrobenzonitrile
• 4-(Trifluoromethyl)cinnamic acid
• 4-(Trifluoromethyl)benzenesulfonamide
• 4-(Trifluoromethoxy)benzonitrile