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1-Methylpiperazine

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1-Methylpiperazine Basic information

Product Name:
1-Methylpiperazine
Synonyms:
  • N-METHYLPIPERAZINE
  • NMPRZ
  • 1-methyl-piperazin
  • 1-METHYLPIPERAZINE FOR SYNTHESIS
  • Cyclizine Related CoMpound A
  • N-Methyl piperazine
  • 4-Methylpiperazine
  • 1-Methylpiperazine, 99+% 100GR
CAS:
109-01-3
MF:
C5H12N2
MW:
100.16
EINECS:
203-639-5
Product Categories:
  • 1
  • Benzotriazoles ,Triazoles
  • Building Blocks
  • C4 to C8
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Nitrogen containing
  • Alpha Sort
  • Heterocyclics
  • M
  • MAlphabetic
  • META - METHChemical Class
  • Volatiles/ Semivolatiles
  • Heterocyclic Building Blocks
  • Piperidines, Piperidones, Piperazines
  • Piperaizine
  • Piperazine derivates
  • Piperazines
  • Building Blocks
Mol File:
109-01-3.mol
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1-Methylpiperazine Chemical Properties

Melting point:
-6 °C
Boiling point:
138 °C(lit.)
Density 
0.903 g/mL at 25 °C(lit.)
vapor density 
3.5 (vs air)
vapor pressure 
12 hPa (20 °C)
refractive index 
n20/D 1.466(lit.)
Flash point:
108 °F
storage temp. 
2-8°C
solubility 
Chloroform (Soluble), Methanol (Soluble)
pka
pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1)
form 
Liquid
Specific Gravity
0.903
color 
Clear
PH
11-12 (50g/l, H2O, 20℃)
explosive limit
1.2-9.9%(V)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
102724
InChIKey
PVOAHINGSUIXLS-UHFFFAOYSA-N
LogP
-0.57 at 25℃
CAS DataBase Reference
109-01-3(CAS DataBase Reference)
NIST Chemistry Reference
Piperazine, 1-methyl-(109-01-3)
EPA Substance Registry System
Piperazine, 1-methyl- (109-01-3)
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Safety Information

Hazard Codes 
T,F,C,Xi
Risk Statements 
10-21-23-34-36/37/38-20/21
Safety Statements 
16-26-36/37/39-45-36
RIDADR 
UN 2734 8/PG 2
WGK Germany 
2
RTECS 
TM1225000
Autoignition Temperature
320 °C
Hazard Note 
Flammable/Toxic/Corrosive/Store under nitrogen
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29335995
Toxicity
LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg

MSDS

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1-Methylpiperazine Usage And Synthesis

Chemical Properties

clear liquid

Uses

1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)

Uses

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Definition

ChEBI: 1-Methylpiperazine is a N-methylpiperazine.

Hazard

Moderate fire risk.

Flammability and Explosibility

Flammable

Safety Profile

Poison by intraperitoneal route. Moderately toxic by inhalation, ingestion, and skin contact. A severe skin and eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

1-Methylpiperazine Preparation Products And Raw materials

Preparation Products

Zopiclone2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxamide2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine(2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanol2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride(3,4-DIAMINO-PHENYL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylic acid2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonitrile3-(4-Methylpiperazin-1-ylmethyl)benzoic acidEthyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate4-[(4-Methylpiperazin-1-yl)methyl]aniline(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamineCHLORCYCLIZINE HYDROCHLORIDE2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone 3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one CHLORCYCLIZINE2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehydeLevofloxacin hydrochloride2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile4-(4-Methylpiperazino)aniline2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid1-METHYL-4-(4-NITROPHENYL)PIPERAZINEEthyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate4-(4-METHYLPIPERAZINOMETHYL)BENZOIC ACID(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACIDClozapine1-METHYL-4-(3-NITROPHENYL)PIPERAZINERimantadine1-METHYL-4-(4-NITROBENZYL)PIPERAZINE1-Amino-4-methylpiperazine1-FORMYL-4-METHYLPIPERAZINE3-(4-Methylpiperazin-1-yl)aniline

Raw materials

MethanolCARBON DIOXIDE1,4-DiazacyclohexanePIPERAZINE HEXAHYDRATEPIPERAZINE DIHYDROCHLORIDE

1-MethylpiperazineSupplier

Yangzhou xinhua chemical co. LTD Gold
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Jinan Junhe Pharmaceutical Co., Ltd Gold
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13475558980
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644535754@qq.com
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1-Methylpiperazine(109-01-3)Related Product Information