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4-(4-Pyridyl)Benzoic Acid

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4-(4-Pyridyl)Benzoic Acid Basic information

Product Name:
4-(4-Pyridyl)Benzoic Acid
Synonyms:
  • 5-TAMRA-PEG4-Methyltetrazine
CAS:
2163772-19-6
MF:
C42H45N7O8
MW:
775.86
Mol File:
2163772-19-6.mol
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4-(4-Pyridyl)Benzoic Acid Usage And Synthesis

Description

TAMRA-PEG4-Methyltetrazine is a fluorescent dye compound which can be labled to other macromolecule via click chemistry with TCO. Rhodamine is a commonly used red fluorescent dye tracer in biology for staining cells, tissues, biomarkers or nanoparticles. It has peak fluorescence emission at 572-575 nm.

Uses

TAMRA-PEG4-methyltetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-methyltetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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