7-HYDROXYCOUMARIN GLUCOSIDE Chemical Properties

Melting point:

221-222℃

alpha 

D18 -80° (c = 10 in pyridine)

Boiling point:

422.63°C (rough estimate)

Density 

1.588

refractive index 

1.5500 (estimate)

storage temp. 

2-8°C

solubility 

DMSO: 1mg/mL

form 

Solid

pka

12.73±0.70(Predicted)

color 

White to off-white

Major Application

metabolomics
vitamins, nutraceuticals, and natural products

InChI

1S/C15H16O8/c16-6-10-12(18)13(19)14(20)15(23-10)21-8-3-1-7-2-4-11(17)22-9(7)5-8/h1-5,10,12-16,18-20H,6H2/t10-,12-,13+,14-,15-/m1/s1

InChIKey

VPAOSFFTKWUGAD-TVKJYDDYSA-N

SMILES

O[C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O)O)CO)OC2=CC(O3)=C(C=C2)C=CC3=O

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

7-HYDROXYCOUMARIN GLUCOSIDE Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Tripterygium wilfordii, Artemisia capillaris, and Glechoma longituba.

Uses

Skimmin is a useful research chemical with neuroprotective effects.

Definition

ChEBI: Skimmin is a member of coumarins and a glycoside.

Biological Activity

Renal protecting, anti-inflammation.

Synthesis

A method for the preparation of 7-hydroxycoumarin glucoside, characterized in that said method consists of the following steps: (1) take the whole herb of horseshoe gold, at room temperature with acetone solution tissue crushing extraction 3 times, each time for 10-30 minutes, the combined extract, concentrated under reduced pressure to the extract; (2) extract the extract with the proportion of 10:1 ethyl acetate - methanol mixed solution for 15-18 countercurrent extraction, the combined extract, decompression Recovery of solvent, the extract; (3) the extract will be dispersed with water, through the polyamide resin column, 30-60% ethanol elution, eluent concentration of the crude product; (4) the crude product will be dissolved in methanol, sampling to the silica gel mesh number of 200-300 of the medium-pressure chromatography column, eluted with a mixture of methanol - dichloromethane, the collection of the target components of the section of the eluent, filtration, concentration and low-temperature drying that is to obtain 7-hydroxycoumarin glucoside.

7-HYDROXYCOUMARIN GLUCOSIDE(93-39-0)Related Product Information

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• 4-METHYLUMBELLIFERYL-BETA-D-GLUCURONIDE TRIHYDRATE
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• 4-METHYLUMBELLIFERYL-BETA-D-GALACTOSIDE-6-SULPHATE SODIUM SALT
• BETA-TRIFLUOROMETHYLUMBELLIFERYL BETA-D-GLUCURONIDE