BAY-218
BAY-218 Basic information
- Product Name:
- BAY-218
- Synonyms:
-
- BAY2335218;BAY-2335218;BAY 2335218;BAY218;BAY 218;BAY-218
- BAY-218
- CPD3504
- BAY-2335218
- AHR antagonist 1
- 4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2-(3-fluorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-3-oxo-
- 6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide
- (S)-6-(4-Chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2，3-dihydropyridazine-4-carboxamide
- CAS:
- 2162982-11-6
- MF:
- C20H17ClFN3O3
- MW:
- 401.82
- Mol File:
- 2162982-11-6.mol
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BAY-218 Chemical Properties
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:80.0(Max Conc. mg/mL);199.09(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);49.77(Max Conc. mM) - form
- Solid
- pka
- 11.81±0.20(Predicted)
- color
- Light yellow to yellow
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BAY-218 Usage And Synthesis
Uses
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses[1].
in vivo
BAY-218 (example 23) (p.o; 30 mg/kg; bid) has good anti-tumor effect combinated with aPD-L1[1].
| Animal Model: | Balb/c mice (subcutaneously CT26 cells)[1] |
| Dosage: | 30 mg/kg |
| Administration: | p.o, bid |
| Result: | Significantly decreased tumors size combinated with aPD-L1. |
References
[1] Norbert Schmees, et al. 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides. WO2017202816A1.
BAY-218Supplier
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Shanghai JiYi Biotechnology Co. Ltd.
- Tel
- 13621943973
- sales@shjiyipharmatech.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com