DIF-3 Chemical Properties

Boiling point:

416.9±45.0 °C(Predicted)

Density 

1.240±0.06 g/cm3(Predicted)

solubility 

DMSO: 46 mg/mL, soluble

form 

solid

pka

5.92±0.45(Predicted)

color 

White to off-white

Safety Information

WGK Germany 

3

DIF-3 Usage And Synthesis

Uses

DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes

Biological Activity

Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.', 'DIF-3 Inhibits cell cycle by inducing G0/G1 arrest.

DIF-3(113411-17-9)Related Product Information

• LABOTEST-BB LT00244818
• (+)-Griseofulvin
• 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
• DIF-3