SECO RAPAMYCIN SODIUM SALT Chemical Properties

Melting point:

120-122°C

storage temp. 

Amber Vial, -20°C Freezer, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale Yellow to Yellow

Stability:

Light Sensitive

SECO RAPAMYCIN SODIUM SALT Usage And Synthesis

Description

Rapamycin is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.

Chemical Properties

Yellow Solid

Uses

A metabolite of Sirolimus

Uses

A decomposition product of Rapamycin (R124000).

SECO RAPAMYCIN SODIUM SALT(148554-65-8)Related Product Information

• Rapamycin
• N-DECANOYLSARCOSINE SODIUM SALT
• SECO RAPAMYCIN SODIUM SALT