ERYTHROMYCIN A DIHYDRATE
ERYTHROMYCIN A DIHYDRATE Basic information
- Product Name:
- ERYTHROMYCIN A DIHYDRATE
- Synonyms:
-
- Roxithromycin Impurity A
- ERYTHROMYCIN A, DIHYDRATE VETRANAL
- Erythromycin A dihydrateQ: What is Erythromycin A dihydrate Q: What is the CAS Number of Erythromycin A dihydrate Q: What is the storage condition of Erythromycin A dihydrate
- Erythromycin A, EvoPure
- CAS:
- 59319-72-1
- MF:
- C37H67NO13.H2O
- MW:
- 751.945
- EINECS:
- 204-040-1
- Product Categories:
-
- Alphabetic
- Chemical Structure
- E
- EQ - EZAntibiotics
- MLS
- Mol File:
- 59319-72-1.mol
ERYTHROMYCIN A DIHYDRATE Chemical Properties
- Melting point:
- 197.6 °C
ERYTHROMYCIN A DIHYDRATE Usage And Synthesis
Biological Activity
Erythromycin dihyrate is a macrolide antibiotic produced by actinomycetes with broad antibacterial activity. It acts by binding to the bacterial 50S ribosomal subunit and inhibits RNA-dependent protein synthesis by blocking transpeptidation and/or translocation reactions without affecting nucleic acid synthesis .
in vitro
Erythromycin dihyrate inhibits growth of P. falciparum with IC 50 and IC 90 values of 58.2 μM and 104.0 μM, respectively .
in vivo
Mice of the ddY strain began to receive Erythromycin dihyrate 7 days after inoculation of EAC cells, and CDF mice begins to receive Erythromycin dihyrate immediately after inoculation of P388 cells. Erythromycin dihyrate (gastric intubation; 0.1-50 mg/ kg; 30-120 days) decreases tumor growth from the dose of 5 mg/kg, mice receiving 1-10 mg/kg of Erythromycin dihyrate survives much longer than control mice, Only 10% of mice treated with 5 mg/kg of Erythromycin dihyrate had no evidence of tumor formation on day 60, and the mice are alive even at 120 days after inoculation. However, treatment with 50 mg/kg of Erythromycin dihyrate shortens mean survival time in tumorbearing mice by 4-5 days when it compares to controls.
| Animal Model: | Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 ce lls |
| Dosage: | 0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg |
| Administration: | Gastric intubation; 30-120 days |
| Result: | Decrease tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortens the MST in tumorbearing mice. |
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ERYTHROMYCIN A DIHYDRATE(59319-72-1)Related Product Information
- Erythromycin sulfamate
- Erythromycin stearate
- ERYTHROMYCIN PROPIONATE
- L-glutamic acid, compound with erythromycin (1:1)
- (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one, (3R,4S,5S, 6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6 -methyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2S,4R,5S,6S)-5-h ydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-1 -oxacyclotetradecane-2,10-dione
- ERYTHROMYCIN PHOSPHATE
- ERYTHROMYCIN LACTOBIONATE (200 MG)
- CLARITHROMYCIN LACTOBIONATE
- (-)-ERYTHROMYCIN HYDRATE
- ERYTHROMYCIN A DIHYDRATE
- Erythromycin Carbonate
- erythromycin 2'-acetate
- Erythromycin ethylsuccinate
- Erythromycin Estolate