CUCURBIT(8)URIL
CUCURBIT(8)URIL Basic information
- Product Name:
- CUCURBIT(8)URIL
- Synonyms:
-
- Cucurbit[8]uril
- Curcubit[8]uril
- Cucurbit[8]uril (CB[8]) hydrate, 99+%
- Cucurbit[8]uril hydrate contains acid of crystalization
- Cucurbit[8]uril hydrate
- 2,20:3,19-Dimethano-2,3,4a,5a,6a,7a,8a,9a,10a,11a,12a,13a,14a,15a,16a,17a,19,20,21a,22a,23a,24a,25a,26a,27a,28a,29a,30a,31a,32a,33a,34a-dotriacontaazabispentaleno[1''''',6''''':5'''',6'''',7'''']cycloocta[1'''',2'''',3'''':3''',4''']pentaleno[1''',6''':5'
- Cucurbit[8]uril (CB[8]) hydrate
- 2,20:3,19-Dimethano-2,3,4a,5a,6a,7a,8a,9a,10a,11a,12a,13a,14a,15a,16a,17a,19,20,21a,22a,23a,24a,25a,26a,27a,28a,29a,30a,31a,32a,33a,34a-dotriacontaazabispentaleno[1''''',6''''':5'''',6'''',7'''']cycloocta[1'''',2'''',3'''':3''',4''']pentaleno[1''',6''':5'',6'',7'']cycloocta[1'',2'',3'':3',4']pentale...
- CAS:
- 259886-51-6
- MF:
- C48H48N32O16
- MW:
- 1329.1
- Product Categories:
-
- Amine-Functional Polymers
- Hydrophilic Polymers
- Polymer Science
- API
- Mol File:
- 259886-51-6.mol
CUCURBIT(8)URIL Chemical Properties
- Density
- 2.71
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- color
- white
- optical activity
- [α]20/D -61°, c =1% in H2O
CUCURBIT(8)URIL Usage And Synthesis
Uses
Cucurbit[8]uril hydrate can be used as ananocontainer in a polyelectrolyte multilayer film.
Definition
ChEBI: Cucurbit[8]uril is a cucurbituril.
Synthesis
496-46-8
462-95-3
80262-44-8
259886-51-6
259886-49-2
259886-50-5
General procedure for the synthesis of cucurbit[n]uril from glyburide and diethoxymethane: Unsubstituted glyburide (19.94 g) and pure methanesulfonic acid (82 mL) were added to a reaction flask and heated to 80 °C. Subsequently, diethoxymethane (35.21 mL) was added slowly and the reaction mixture was warmed up to 100 °C (internal temperature) and kept for 18 hours. Upon completion of the reaction, the mixture was cooled and poured into acetone (410 mL) and a brown powder was precipitated. The product composition was analyzed by 1H NMR to give cucurbit[5]uril (8%), cucurbit[6]uril (42%), cucurbit[7]uril (43%), cucurbit[8]uril (7%), cucurbit[9]uril (0%), cucurbit[10]uril (0%) and cucurbit[13]uril (0%). In addition, the residual formaldehyde content was 34 ppm by HPLC.
in vivo
Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice[2].
References
[1] Patent: WO2018/115822, 2018, A1. Location in patent: Page/Page column 16
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