2-Fluoropyridine-5-boronic acid pinacol ester Chemical Properties

Melting point:

29-33 °C(lit.)

Boiling point:

304.2±27.0 °C(Predicted)

Density 

1.09±0.1 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to lump

pka

-0.44±0.12(Predicted)

color 

White to Light yellow

InChI

InChI=1S/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3

InChIKey

ZKSRQMCKFLGPQU-UHFFFAOYSA-N

SMILES

C1(F)=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2933399990

2-Fluoropyridine-5-boronic acid pinacol ester Usage And Synthesis

Uses

2-Fluoropyridine-5-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

General procedure for the synthesis of 2-fluoro-5-bromopyridine and pinacol ester of bisboronic acid from 2-fluoro-5-bromopyridine and pinacol ester of bisboronic acid: under nitrogen protection, Pd(dppf)Cl2 (4.16 g, 5.68 mmol) was added in a single step to a solution containing 5-bromo-2-fluoro-pyridine (10 g, 56.82 mmol), pinacol ester of bisboronic acid (21.64 g, 85.23 mmol) and potassium acetate (16.73 g, 170.46 mmol) in a solution of dioxane (100 mL). The mixture was stirred at room temperature for 10 minutes and then heated to reflux for 6 hours. Upon completion of the reaction, the solvent was removed by direct evaporation and the residue was purified by flash silica gel column chromatography to afford the target product 2-fluoropyridine-5-boronic acid pinacol ester (10.5 g, 82.85% yield). The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 8.59 (s, 1H), 8.15 (dt, J = 1.76, 8.41 Hz, 1H), 6.91 (dd, J = 2.26, 8.28 Hz, 1H), 1.35 (s, 12H).

References

[1] Patent: EP3333157, 2018, A1. Location in patent: Paragraph 0255; 0256
[2] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0215
[3] Patent: WO2006/38116, 2006, A2. Location in patent: Page/Page column 40
[4] Patent: EP2891656, 2015, A1. Location in patent: Paragraph 0245
[5] Patent: WO2006/126081, 2006, A2. Location in patent: Page/Page column 52-53

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