PIMARIC ACID
PIMARIC ACID Basic information
- Product Name:
- PIMARIC ACID
- Synonyms:
-
- (1R,4aR,4bS,7S,10aR)-7-Ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-triMethyl-1-phenanthrenecarboxylic Acid
- 13α-Methyl-13-vinylpodocarp-8(14)-en-15-oic acid
- PIMARIC ACID
- 1-phenanthrenecarboxylicacid,7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahyd
- 7-trimethyl-,[1theta-(1alpha,4abeta,4balpha,7beta,10aalpha)]-ro-4a
- 13-alpha-methyl-13-vinylpodocarp-8(14)-en-15-oic acid
- 1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1R,4aR,4bS,7S,10aR)-
- 8(14),15-PiMaradien-18-oic Acid
- CAS:
- 127-27-5
- MF:
- C20H30O2
- MW:
- 302.45
- Product Categories:
-
- Activators
- Aliphatics
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 127-27-5.mol
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PIMARIC ACID Chemical Properties
- Melting point:
- 217-219°
- alpha
- D18 +74.7° (c = 0.4 in chloroform); D20 +87.3° (in chloroform)
- Boiling point:
- bp18 282°
- Density
- 1.0434 (rough estimate)
- refractive index
- 1.4800 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble,Water: soluble
- pka
- 4.68±0.60(Predicted)
- form
- Solid
- color
- White to off-white
- LogP
- 6.731 (est)
- EPA Substance Registry System
- Pimaric acid (127-27-5)
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PIMARIC ACID Usage And Synthesis
Description
Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.
Uses
A novel activators of large-conductance Ca2+-activated K+ channel α-subunit.
Definition
ChEBI: (+)-Pimaric acid is a diterpenoid.
PIMARIC ACIDSupplier
Chembest Research Laboratories Limited
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- +86-21-20908456
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Chemsky (shanghai) International Co.,Ltd
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- 021-50135380
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BioBioPha Co., Ltd.
- Tel
- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
ChemStrong Scientific Co.,Ltd
- Tel
- 0755-0755-66853366 13670046396
- sales@chem-strong.com
Wuxi Zhongkun Biochemical Technology Co., Ltd.
- Tel
- 0510-85629785 18013409632
- sales@reading-chemicals.com
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PIMARIC ACID(127-27-5)Related Product Information
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- PIMARIC ACID
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