Boc-Val-Ala-PAB Chemical Properties

Boiling point:

653.7±55.0 °C(Predicted)

Density 

1.166±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Solid

pka

11.26±0.46(Predicted)

color 

White to off-white

Boc-Val-Ala-PAB Usage And Synthesis

Description

Boc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Boc-Val-Ala-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate (ADCs)[1][2].

References

[1] HP Wilson, et al. Pyrrolobenzodiazepines and conjugates thereof: World Intellectual Property Organization, WO2016037644. 2016-03-17.
[2] HP Wilson, et al. Preparation of pyrrolobenzodiazepine dimers and their conjugates with cell binding agents, especially pyrrolobenzodiazepine dimer drug linker antibody conjugates and their use for treating proliferative diseases, particularly cancer: World Intellectual Property Organization, WO2016038383. 2016-03-17