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Cinepazide maleate

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Cinepazide maleate Basic information

Product Name:
Cinepazide maleate
Synonyms:
  • 1-(1-Pyrrolidinylcarbonyl)methyl)-4-(3',4',5'-trimethoxycinnamoyl)
  • 1-((1-pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazinem
  • 1-(4-((3’,4’,5’-trimethoxycinnamoyl)-1-piperazinyl)acetyl)pyrrolidinemaleate
  • 4-(3,4,5-trimethoxycinnamoyl)-1-(1-pyrrolidinyl)carbonylmethylpiperazinemale
  • brendil
  • 2-Propen-1-one, 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-, (2Z)-2-butenedioate (1:1)
  • (E)-1-(4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one maleate
  • maleatedecinepazide
CAS:
26328-04-1
MF:
C26H35N3O9
MW:
533.57
EINECS:
247-613-1
Product Categories:
  • Pharmaceutical intermediate
Mol File:
26328-04-1.mol
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Cinepazide maleate Chemical Properties

Melting point:
135°
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White
Water Solubility 
H2O: 20mg/mL, clear
Merck 
14,2291
CAS DataBase Reference
26328-04-1(CAS DataBase Reference)
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Safety Information

HS Code 
2933.59.5300
Toxicity
LD50 in mice, rats (mg/kg): 1000, 1310 orally; 617, 414 i.v. (Pourrias)
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Cinepazide maleate Usage And Synthesis

Uses

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

Uses

Cinepazide Maleate, is a vasodilator used in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases.It appears to work by potentiating A2 adenosine receptors.

Biological Activity

Cinepazide maleate is a vasodilator used clinically in China used in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases. Cinepazide maleate is thought to act as a potentiator of adenosine A2 receptors and has also been characterized as a calcium channel blocker. It was withdrawn for agranulocytosis in several countries.

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