(-)-SPARTEINE Chemical Properties

Melting point:

30.5°C

Boiling point:

137-138 °C1 mm Hg(lit.)

alpha 

D21 -16.4° (c = 10 in abs alc)

Density 

1.02 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.528(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethanol (Slightly)

form 

liquid

pka

2.24, 9.46(at 20℃)

color 

Light Yellow to Yellow

optical activity

[α]/D -17.5±1.5°, c = 1 in ethanol

Water Solubility 

3.04g/L(25 ºC)

Merck 

14,8737

BRN 

82447

LogP

3.210 (est)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36

RIDADR 

3140

WGK Germany 

3

RTECS 

WG5950000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2933399990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

(-)-SPARTEINE Usage And Synthesis

Description

Sparteine is effective against sinoatrial and atrial tachycardias, atrial extrasystoles, and also against ventricular arrhythmias . Despite prolongation of the myocardial refractory period in vitro, theECGtimes are not prolonged in vivo.

Chemical Properties

Viscous oily liquid; boils around 180°C(356°F); density 1.02 at 20°C (68°F); stronglybasic, a 0.01 M soln. has pH 11.6; slightlysoluble in water (0.3 g/100 mL), dissolvesreadily in alcohol, ether, or chloroform.

Uses

Sparteine occurs in yellow and black lupinbeans (Lupinus luteus L. and L. niger). Italso occurs in other Lupinus species aswell as in Cytisus and Spartium species.Therapeutically, it is used as an oxytocicagent.

Definition

ChEBI: Sparteine is a quinolizidine alkaloid and a quinolizidine alkaloid fundamental parent.

Health Hazard

Toxic actions of sparteine are similar to thoseof coniine but are much less toxic than thoseof coniine. The toxic symptoms in mice weretremor, muscle contraction, and respiratorydistress. An intraperitoneal dose lethal toguinea pigs is 23 mg/kg.
LD50 value, oral (mice): 220 mg/kg.

(-)-SPARTEINE(90-39-1)Related Product Information

• Potassium perrhenate
• Glycyrrhizic acid
• Gallic acid monohydrate
• Calcium oxide
• Diphenhydramine Hydrochloride
• (-)-Huperzine A
• Sophoridine
• Vitexin
• (-)-Sparteine sulfate pentahydrate
• sparteine sulphate ,(-)-SPARTEINE SULFATE SALT,SPARTEINE SULFATE
• Sparteine d-isomer,d-Sparteine
• （＋）2，3－Dehydro-10-oxo-α-isosparteine
• SPARTEINE (BASE AND/OR UNSPECIFIED SALTS)
• sparteine camsilate
• sparteine N-16-oxide
• (sparteine-N,N')(maleonitriledithiolato-S,S')copper(II)
• Sparteine N-oxide
• Sparteine monoperchlorate,Sparteine perchlorate