OXANTEL PAMOATE
OXANTEL PAMOATE Basic information
- Product Name:
- OXANTEL PAMOATE
- Synonyms:
-
- 2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy-, compd. with 3-(1E)-2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenylphenol (1:1)
- 1-methyl-2-(3-hydroxyphenylethenyl)-1,4,5,6-tetrahydropyrimidine compound with 4,4'-methylenebis(3-hydroxy-2-naphthoic acid)
- 4,4'-Methylenebis(3-hydroxy-2-naphthoic) acid, compound with (E)-3-(2-(1,4,5,6-tetrahydro-1-methylpyrimidin-2-yl)vinyl)phenol (1:1)
- Einecs 272-332-6
- Phenol, 3-(2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenyl), (E)-, 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylate) (1:1) (salt)
- 1-METHYL-2-[3-HYDROXYPHENYLETHENYL]-1,4,5,6-TETRAHYDROPYRIMIDINE COMPOUND WITH 4,4'-METHYLENEBIS[3-HYDROXY-2-NAPHTHOIC ACID]
- OXANTEL PAMOATE
- 4,4'-methylenebis[3-hydroxy-2-naphthoic] acid, compound with (E)-3-[2-(1,4,5,6-tetrahydro-1-methylpyrimidin-2-yl)vinyl]phenol (1:1)
- CAS:
- 68813-55-8
- MF:
- C49H48N4O8
- MW:
- 820.93
- EINECS:
- 272-332-6
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- MOTILIUM
- Mol File:
- 68813-55-8.mol
OXANTEL PAMOATE Chemical Properties
- Melting point:
- >224°C (dec.)
- storage temp.
- Amber Vial, Refrigerator, Under inert atmosphere
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- form
- Solid
- color
- White to Off-White
- InChIKey
- WSYDAPQDBDVYIO-QEFJDTIGSA-N
MSDS
- Language:English Provider:SigmaAldrich
OXANTEL PAMOATE Usage And Synthesis
Uses
antiemetic, dopamine antagonist
Uses
Oxantel Pamoate is used as an anthelmintic drug.
Definition
ChEBI: Oxantel pamoate is a naphthoic acid.
brand name
Telopar (Pfizer).
in vivo
The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus[1].
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