1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Chemical Properties

Melting point:

-20 °C

Boiling point:

146 °C44 mm Hg(lit.)

Density 

1.06 g/mL at 25 °C(lit.)

vapor pressure 

0.5 hPa (57 °C)

refractive index 

n20/D 1.488(lit.)

Flash point:

121 °C

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Liquid

pka

-0.65±0.20(Predicted)

color 

Clear colorless to slightly yellow

PH

11 (100g/l, H2O, 20℃)

explosive limit

1.6-9.3%(V)

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

110562

Dielectric constant

36.119999999999997

Stability:

Hygroscopic

InChIKey

GUVUOGQBMYCBQP-UHFFFAOYSA-N

LogP

0.05 at 25℃

CAS DataBase Reference

7226-23-5(CAS DataBase Reference)

EPA Substance Registry System

2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- (7226-23-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36-43-62-41

Safety Statements 

23-26-36/37/39-45

WGK Germany 

2

RTECS 

UW7582500

F 

3-10

Autoignition Temperature

255 °C

TSCA 

Yes

HS Code 

29335995

Toxicity

LD50 orally in Rabbit: 1770 mg/kg

MSDS

• Language:English Provider:DMPU
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Usage And Synthesis

Chemical Properties

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is clear colorless to slightly yellowish liquid

Uses

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is a versatile organic solvent in and less toxic than HMPA. It is mainly applied in the synthesis of pharmaceuticals and agrochemicals. DMPU is also used in the electronics industry.

Uses

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is a versatile solvent used in the N-alkylation of chiral and O-alkylation of aldoses. It is involved in the preparation of poly(aryl ethers). It is a cyclic urea and used as a polar aprotic organic solvent. Further, it reacts with trifluoro-methanesulfonic acid anhydride to prepare 2,2'-oxy-bis(1,3-dimethyl-tetrahydropyrimidinium) bis(trifluoromethanesulfonate).

Uses

Versatile solvent employed in N-alkylation of chiral, primary amines, O-alkylation of aldoses, and in the synthesis of poly(aryl ethers).

Flammability and Explosibility

Non flammable

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