MITRAGYNINE PICRATE Chemical Properties

Melting point:

92-95°C

alpha 

D +39° (chloroform)

Boiling point:

bp5 230-240°

Density 

1.22±0.1 g/cm3 (20 ºC 760 Torr)

Flash point:

9℃

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

18.35±0.60(Predicted)

color 

Light Orange to Dark Beige to Very Dark Yellow

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25-36/37/38-22

Safety Statements 

7-16-36/37-45-26

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

1

HS Code 

29339900

Hazardous Substances Data

4098-40-2(Hazardous Substances Data)

MITRAGYNINE PICRATE Usage And Synthesis

Description

This alkaloid has been isolated from Mitragyna speciosa Korth, and is amorphous although it yields a series of crystalline salts and derivatives. The hydrochloride crystallizes as colourless leaflets from EtOH-Et20 with m.p. 243°C; the picrate forms thin, orange-red needles, m.p. 223-4°C and the methiodide is a pale yellow powder which, although amorphous, has a sharp melting point of 21 1. 5°C. The alkaloid also forms compounds with acetic acid, m.p. 142°C, decomposing at 175-6°, and with trichloroacetic acid, m.p. 157°C.
Mitragynine exerts a general depressant effect on plain muscle and facilitates the passage of autonomic impulses. It is, however, ineffective against pathogenic organisms.

Chemical Properties

White to Off-White Solid

Uses

A neurochemical, having both stimulant and opiate-like effects depending on the dosage. Currently, Mitragynin is being investigated for its ability to treat hard drug addiction.

Uses

Mitragynine is a neurochemical, having both stimulant and opiate-like effects depending on the dosage. Currently, Mitragynine is being investigated for its ability to treat hard drug addiction.

Definition

ChEBI: Mitragynine is a monoterpenoid indole alkaloid.

References

Field., J. Chern. Soc., 119,887 (1921)
Raymond-Hamet, Millat., Bull. sci. pharrnacol., 40, 593 (1933)
lng, Raison., J. Chern. Soc., 986 (1939)
Loudon., Chern. Soc. Spec. Publ., 3, 12 (1955)
Hendrickson., Chern. & Ind., 713 (1961)
Joshi, Raymond-Hamet, Taylor., ibid, 573 (1963)
Pharmacology: Grewal., J. Pharrn. expo Ther., 46,251 (1932)

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