H-TYR-PHE-OH Chemical Properties

Boiling point:

642.2±55.0 °C(Predicted)

Density 

1.300±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

pka

3.40±0.10(Predicted)

form 

Solid

color 

White to off-white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

H-TYR-PHE-OH Usage And Synthesis

Uses

H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4].

Definition

ChEBI: Tyr-Phe is a dipeptide formed from L-tyrosine and L-phenylalanine residues. It has a role as a metabolite.

References

[1] Zhu Wei, et al. Biomarker containing keratin type II cytoskeleton 1b for differentiating benign thyroid nodules and thyroid cancer: China, CN114264828A[P]. 2022-04-01.
[2] Enari Hiroyuki, et al. Angiotensin converting enzyme (ACE)-inhibiting peptides, ACE inhibitors containing the peptides, their uses, and manufacture of the peptides from shark cartilage: Japan, JP2005154326A[P]. 2005-06-16.
[3] Mao Xiangchao, et al. Method for preparing cod fish peptide with xanthine oxidase inhibitory activity: China, CN113005166A[P]. 2021-06-22.
[4] Hsueh PC, et al. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Anal Chim Acta. 2020 Sep 1;1128:238-250. DOI:10.1016/j.aca.2020.06.022

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