CASTICIN
CASTICIN Basic information
- Product Name:
- CASTICIN
- Synonyms:
-
- CASTICIN
- 5,3'-DIHYDROXY-3,6,7,4'-TETRAMETHOXYFLAVONE
- 3',5-DIHYDROXY-3,4',6,7-TETRAMETHOXY FLAVONE
- VITEXICARPIN
- VITEXICARPIM
- Casticin (Vitexicarpin)
- Casticin (25 mg)
- CASTICIN WITH HPLC
- CAS:
- 479-91-4
- MF:
- C19H18O8
- MW:
- 374.34
- Product Categories:
-
- Hexa-substituted Flavones
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 479-91-4.mol
CASTICIN Chemical Properties
- Melting point:
- 186-187 °C
- Boiling point:
- 617.7±55.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ethanol: soluble1mg/mL, clear, colorless to light yellow
- form
- Solid
- pka
- 6.13±0.40(Predicted)
- color
- Yellow
- BRN
- 1300392
- InChI
- InChI=1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
- InChIKey
- PJQLSMYMOKWUJG-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C(OC)C(O)=C2)OC2=CC(OC)=C(OC)C(O)=C2C(=O)C=1OC
- CAS DataBase Reference
- 479-91-4(CAS DataBase Reference)
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29329990
CASTICIN Usage And Synthesis
Chemical Properties
Soluble in a mixed solvent of DMSO, chloroform and methanol, insoluble in petroleum ether and chloroform. Derived from the Umbelliferae plant Foeniculum vulgare
Uses
Casticin is a biological compound known to induce human glioma cell death through an apoptotic mechanism and disruption of the mitotic cycle.
Definition
ChEBI: A tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4' have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii.
in vivo
Casticin (20 mg/kg, p.o.) has toxic effect on the liver in mice with CCl4-and BDL-induced hepatic injury. Casticin attenuates liver fibrosis induced by CCl4 or BDL in vivo. Casticin inhibits HSC activation and collagen matrix expression by blocking TGF-β/Smad signaling in vivo[2].
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CASTICIN(479-91-4)Related Product Information
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