4-Propoxyphenol Chemical Properties

Melting point:

54-56 °C(lit.)

Boiling point:

234.66°C (rough estimate)

Density 

1.0505 (rough estimate)

refractive index 

1.4910 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

10.34±0.15(Predicted)

color 

Light Brown

CAS DataBase Reference

18979-50-5(CAS DataBase Reference)

NIST Chemistry Reference

4-Propoxyphenol(18979-50-5)

EPA Substance Registry System

Phenol, 4-propoxy- (18979-50-5)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

22-24/25-37/39-26

WGK Germany 

3

TSCA 

Yes

HS Code 

29071990

MSDS

• Language:English Provider:Hydroquinone monopropyl ether
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Propoxyphenol Usage And Synthesis

Chemical Properties

BEIGE CRYSTALLINE POWDER

Uses

Intermediates of Liquid Crystals

Synthesis

To a mixture of p-benzoquinone (1 mmol) and n-propanol (4.0 mL) was added Amberlyst-15 (40 mg), and the mixture was reacted at reflux for 4-7 hours at 100 °C until the p-benzoquinone was fully reacted (monitored by TLC). After completion of the reaction, the reaction mixture was filtered and the residue was washed with ethyl acetate (25 mL). The washed solution was combined with the filtrate, water (25 mL) was added to the combined solution, and the aqueous layer was extracted with ethyl acetate (2 x 10 mL). The ethyl acetate extracts were combined and dried with anhydrous Na2SO4. The dried extracts were concentrated under reduced pressure and the resulting crude product was purified by silica gel column chromatography with the eluent being a mixed solvent of ethyl acetate-petroleum ether. The purified product was further crystallized using CH2Cl2-petroleum ether mixed solvent. All the synthesized 4-propoxyphenols were characterized by physical properties, elemental analysis and spectral data.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 1, p. 86 - 89

4-Propoxyphenol(18979-50-5)Related Product Information

• 2-Ethoxyphenol
• 2-Butoxyethanol
• Allyl ether
• 4-Chlorophenol
• Styrene-acrylic latex
• 4-Hydroxybenzaldehyde
• 2-(4-HYDROXYPHENYL)PROPIONIC ACID
• Butylated hydroxyanisole
• 4-Methoxyphenol
• Guaiacol
• 4-Aminophenol
• Methylparaben
• 3-Methoxyphenol
• 2-Phenylphenol
• 4-Hydroxyphenylacetic acid
• p-(2-Methoxyethyl) phenol
• Ethylbenzene
• Protocatechuic acid