Glyceryl monothioglycolate Chemical Properties

Boiling point:

244℃[at 101 325 Pa]

Density 

1.315[at 20℃]

vapor pressure 

0.001Pa at 25℃

pka

8.4[at 20 ℃]

Water Solubility 

1000g/L at 20℃

InChI

InChI=1S/C5H10O4S/c6-1-4(7)2-9-5(8)3-10/h4,6-7,10H,1-3H2

InChIKey

DOGJSOZYUGJVKS-UHFFFAOYSA-N

SMILES

C(O)(CO)COC(=O)CS

LogP

0.45 at 22℃

EPA Substance Registry System

Acetic acid, mercapto-, monoester with 1,2,3-propanetriol (30618-84-9)

Glyceryl monothioglycolate Usage And Synthesis

Allergy symptoms

Glyceryl mono thioglycolate has been recognized as a potential sensitizer and has been reported to cause allergic contact dermatitis in both hairdressers and clients. Hairdressers most commonly manifest their allergy as a hand dermatitis, whereas the clients most often have a dermatitis involving the scalp, face, ears, and neck. In preliminary patch testing, hair recently permanently woven with a solution containing glyceryl monothioglycolate produced positive results. These observations suggested that the permanent-waved hair may retain glyceryl monothioglycolate or a cross-reacting product. Positive reactions were seen in hair collected as long as 3 months after the permanent. This suggests that a glyceryl monothioglycolate-related allergen is retained in hair for up to 3 months after the permanent, which may explain the long-lasting dermatitis in clients sensitive to glyceryl monothioglycolate[1].

Description

Glyceryl monothioglycolate is an acid permanent wave ingredient, which induces contact dermatitis in hairdressers.

Uses

Glyceryl monothio-glycolate is a component in "acid" permanent waving formulations, mainly for use in hairdressing salons.

Definition

ChEBI: Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol. As a component of developer solutions in permanent wave products, it is the second most frequent allergen in hairdressers and avoidance of acid permanent waves is mandatory. It has a role as an allergen.

Hazard

A mild skin and eye irritant

Flammability and Explosibility

Non flammable

Contact allergens

It is an acid permanent-wave ingredient, which induces contact dermatitis in hairdressers.

References

[1] Lynne H. Morrison M.D. , Frances J. Storrs M.D. “Persistence of an allergen in hair after glyceryl monothioglycolate—containing permanent wave solutions.” Journal of the American Academy of Dermatology 19 1 (1988): Pages 52-59.

Glyceryl monothioglycolate(30618-84-9)Related Product Information

• Glyceryl monostearate
• Folic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Glyceryl Monooleate
• Glycerol
• Citric acid
• Stearic acid
• Triglycerol monostearate
• GLYCERYL MONORICINOLEATE
• 2-Ethylhexyl mercaptoacetate
• Monostearin
• Sodium thioglycolate
• Diacetin
• POLYGLYCERYL-10 OLEATE
• Monoacetin
• Calcium thioglycolate
• Mercaptoacetic acid
• Ammonium thioglycolate