1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Chemical Properties

Melting point:

115.0 to 119.0 °C

Boiling point:

465.5±30.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: ≥20mg/mL

form 

powder

color 

off-white to light tan

Sensitive 

Light Sensitive

Safety Information

Hazard Codes 

Xi

WGK Germany 

3

HS Code 

2933.99.9000

HazardClass 

IRRITANT

1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Usage And Synthesis

Uses

Oncrasin 1 is a proapoptotic compound.

Definition

ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.

Biological Activity

Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .

storage

+4°C

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