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ASARININ

Basic information Safety Supplier Related

ASARININ Basic information

Product Name:
ASARININ
Synonyms:
  • (-)-SESAMINE
  • (-)-ASARININ
  • ASARININ
  • EPI-SESAMIN
  • (-)-5,5'-[(1R,3aα,4S,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[1,3-benzodioxole]
  • 5,5'-[(1R,3aα,4S,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(1,3-benzodioxole)
  • L-Asarinin
  • 5-[4-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-1-yl]-1,3-benzodioxole
CAS:
133-04-0
MF:
C20H18O6
MW:
354.35
Product Categories:
  • Lichen Products
Mol File:
133-04-0.mol
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ASARININ Chemical Properties

Melting point:
121°
alpha 
D20 -118.6°; D23 -122° (chloroform)
Boiling point:
504.4±50.0 °C(Predicted)
Density 
1.385±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), DMSO (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
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ASARININ Usage And Synthesis

Description

Asarinin is a lignan that has been found in A. sieboldii. It is an epimer of sesamin and a noncompetitive inhibitor of Δ5-desaturase (Ki = 0.28 mM). It is selective for Δ5-desaturase over Δ6- and Δ9-desaturase. Asarinin is cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC50s = 38.45 and 60.87 μM, respectively) but not immortalized ovarian surface epithelial cells (IC50 = >200 μM). It induces apoptosis and activates caspase-3, -8, and -9 in A2780 and SKOV3 cells.

Uses

l-Asarinin in combination with pellitorine is a potential larvicides for the control of insecticide-resistant mosquito populations. Possesses antimicrobial activity.

target

IL Receptor | IFN-γ | CXCR | TLR

ASARININSupplier

Chembest Research Laboratories Limited
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400-1166-196 18981987031
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0411-62910999 13889544652
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BioBioPha Co., Ltd.
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0871-65217109 13211707573;
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ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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shyysw007@163.com
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