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3-Amino-4-hydroxybenzenesulphonamide

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3-Amino-4-hydroxybenzenesulphonamide Basic information

Product Name:
3-Amino-4-hydroxybenzenesulphonamide
Synonyms:
  • 3-amino-4-hydroxybenzenesulphonamide
  • 3-AMINO-4-HYDROXYBENZENESULFONAMIDE
  • 2-AMINOPHENOL-4-SULFONAMIDE
  • 2-AMINOPHENOL-4-SULFONYL AMIDE
  • 2-AMINOPHENOL-4-SULFOAMINE
  • 2-Amino-1-phenol-4-sulfonylamdie
  • 2-Aminophenlo-4-sulfonamide
  • 2-Aminophenol-4-sulfamide
CAS:
98-32-8
MF:
C6H8N2O3S
MW:
188.2
EINECS:
202-657-0
Product Categories:
  • Intermediates of Dyes and Pigments
  • SULFONAMIDE
  • Benzene derivates
Mol File:
98-32-8.mol
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3-Amino-4-hydroxybenzenesulphonamide Chemical Properties

Melting point:
199-201°C
Boiling point:
454.5±55.0 °C(Predicted)
Density 
1.580±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
7?+-.0.20(Predicted)
color 
White to Gray to Brown
CAS DataBase Reference
98-32-8(CAS DataBase Reference)
EPA Substance Registry System
Benzenesulfonamide, 3-amino-4-hydroxy- (98-32-8)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
2935.90.9500
HazardClass 
IRRITANT
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3-Amino-4-hydroxybenzenesulphonamide Usage And Synthesis

Chemical Properties

Light brown crystal

Uses

3-Amino-4-hydroxybenzenesulfonamide is a reagent used to synthesize antagonists for somatostatin receptor subtype 5 (SST5R). It also has utility in dye applications.

Production Methods

2-nitrochlorobenzene is sulfochlorinated with chlorosulfuric acid; the resulting sulfochloride is treated with ammonia to give 4-chloro-3-nitrobenzenesulfonamide; chlorine is replaced by hydroxyl by heating the product at 100 ℃ in aqueous sodium hydroxide solution. Finally, the hydroxybenzenesulfonamide is reduced with iron turnings to obtain 3-Amino-4-hydroxybenzenesulphonamide.

3-Amino-4-hydroxybenzenesulphonamide Preparation Products And Raw materials

Preparation Products

Raw materials

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