4-Pyrrolidinopyridine Chemical Properties

Melting point:

54-58 °C(lit.)

Boiling point:

171-173 °C (20.2527 mmHg)

Density 

1.0628 (rough estimate)

refractive index 

1.5378 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

methanol: 0.1 g/mL, clear

pka

9.58±0.10(Predicted)

form 

Crystalline Mass, Crystals and/or Chunks

color 

White to yellow to light brown

PH

10.5 (3g/l, H2O, 21℃)

Water Solubility 

3 g/L (21 ºC)

BRN 

472443

InChIKey

RGUKYNXWOWSRET-UHFFFAOYSA-N

CAS DataBase Reference

2456-81-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

25-34-41-23/24/25

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2923 8/PG 3

WGK Germany 

3

F 

8-10-23

HazardClass 

8

PackingGroup 

II

HS Code 

29333999

MSDS

• Language:English Provider:4-(Pyrrolidin-1-yl)pyridine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Pyrrolidinopyridine Usage And Synthesis

Description

4-Pyrrolidinopyridine is the pyridine derivative. It can be used as catalyst employed in polymerization reactions or Hypernucleophilic acylation catalyst. For example, it can be used as the catalyst for the geometry-selective (E-selective) acylation of tetrasubstituted α, α'-alkenediols. It can also be used as the ligand in metal complexes such as the Chloride and pseudohalide hydride-carbonyl ruthenium(II) complexes.

Chemical Properties

white to light brown crystalline mass

Uses

Catalyst employed in polymerization reactions. Ligand in metal complexes.

Synthesis Reference(s)

Synthetic Communications, 9, p. 251, 1979 DOI: 10.1080/00397917908064147
Synthesis, p. 985, 1988 DOI: 10.1055/s-1988-27777

References

http://www.sigmaaldrich.com/catalog/product/aldrich/213373?lang=en&region=US
http://www.sigmaaldrich.com/catalog/product/sial/83275?lang=en&region=US
Yamanaka M et al. "Origin of High E -Selectivity in 4-Pyrrolidinopyridine-Catalyzed Tetrasubstituted α,α′-Alkenediol: A Computational and Experimental Study." Journal of Organic Chemistry 80.6(2015):3075-82.
J. G. Ma?ecki, and A. Maroń. "Chloride and pseudohalide hydride-carbonyl ruthenium(II) complexes with 4-pyrrolidinopyridine as co-ligand."Transition Metal Chemistry 38.2(2013):133-142.

4-Pyrrolidinopyridine(2456-81-7)Related Product Information

• Pyridine
• Cetylpyridinium chloride
• 1-Hexadecylpyridinium bromide
• N-Methyl-2-pyrrolidone
• Polyvinylpyrrolidone
• L-N-[(4'-BOC)PIPERIDINO]PROLINE
• METHYL-2-PYRROLIDONE
• 3-Dodecyl-1-(2,2,6,6-tetramethyl-4-piperidyl)pyrrolidine-2,5-dione
• (S)-(-)-4-PYRROLIDINOPYRINDINYL(PENTAMETHYLCYCLOPENTADIENYL)IRON
• 2-PYRROLIDIN-2-YLPYRIDINE
• 6-(1-PYRROLIDINYL)NICOTINALDEHYDE
• Pyrrole
• L-N-(4'-N-CBZ-PIPERIDINO)PROLINE
• 4-(1-pyrrolidinyl)piperidine dihydrochloride
• N-(1-ACETYL-2,2,6,6-TETRAMETHYL-4-PIPERIDINYL)-2-DODECYLSUCCINIMIDE
• (S)-N-[4'-BENZYL)PIPERIDINO]PROLINE
• 2-DODECYL-N-(1,2,2,6,6-PENTAMETHYL-4-PIPERIDINYL)SUCCINIMIDE
• 4-Pyrrolidinopyridine