DESIPRAMINE HYDROCHLORIDE
DESIPRAMINE HYDROCHLORIDE Basic information
- Product Name:
- DESIPRAMINE HYDROCHLORIDE
- Synonyms:
-
- Desipramine solution hydrochloride
- RMI-9384A
- 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanaminehydrochloride
- Desipramine Hydrochloride (125 mg)
- Desipramine Hydrochloride (125 mg)I0E2831.000mg/mg(dr)
- 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine monohydrochloride
- 5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride
- 10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepinehydrochloride
- CAS:
- 58-28-6
- MF:
- C18H23ClN2
- MW:
- 302.84
- EINECS:
- 200-373-1
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Biogenic Amine Transport Inhibitors
- Biogenic Amine Transport InhibitorsObesity Research
- Neurotransmission
- Neurotransmission (Obesity)
- Neurotransmitters
- Adrenoceptor
- NORPRAMIN
- Mol File:
- 58-28-6.mol
DESIPRAMINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 214-2160C
- Flash point:
- 11 °C
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- white to off-white
- Water Solubility
- Soluble to 100 mM in water
Safety Information
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-36/37/38-42/43-48/23/24/25-23/24/25-11-39/23/24/25
- Safety Statements
- 7-16-36/37-45-26-24-22
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 3
- RTECS
- HO0525000
- HS Code
- 2933996100
- Toxicity
- LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte)
MSDS
- Language:English Provider:SigmaAldrich
DESIPRAMINE HYDROCHLORIDE Usage And Synthesis
Chemical Properties
White To Off-White Solid
Originator
Pertofran,Geigy,UK,1963
Uses
Desipramine hydrochloride has been used:
- to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
- to protect unselective damage to the?noradrenergic system
- as a norepinephrine re-uptake inhibitor to treat rats for lesioning
Uses
Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
Uses
Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
Definition
ChEBI: The hydrochloride salt of desipramine.
Manufacturing Process
Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.
brand name
Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).
Therapeutic Function
Psychostimulant
General Description
The structure and salient properties of desipramine hydrochloride,10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride(Norpramin, Pertofrane), are discussed under the heading,Imipramine. Among tricyclics, desipramine would be consideredwhen few anticholinergic effects or a low level of sedationare important. It is a SNERI.
Biological Activity
Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
Biochem/physiol Actions
Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: decreased urine volume, sodium level changes, chlorine level changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO, and HCI.
storage
Desiccate at +4°C
DESIPRAMINE HYDROCHLORIDESupplier
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- 010-82848833 400-666-7788
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- 821-50328103-801 18930552037
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- 021-50135380
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- 86-21-63210123
- sj_scrc@sinopharm.com
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
DESIPRAMINE HYDROCHLORIDE(58-28-6)Related Product Information
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