N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine Basic information
- Product Name:
- N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
- Synonyms:
-
- N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
- N2,N?-bis(2-Methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
- 2,4-Pyrimidinediamine, N2,N4-bis(2-methyl-1H-indol-5-yl)-
- 2-N,4-N-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
- AZA1, 10 mM in DMSO
- Cdc42/Rac1 Dual Inhibitor, AZA1
- AZA1 (Synonyms: Rac1/Cdc42-IN-1)
- AZA1（Rac1/Cdc42-IN-1）
- CAS:
- 1071098-42-4
- MF:
- C22H20N6
- MW:
- 368.43
- Mol File:
- 1071098-42-4.mol
N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine Chemical Properties
- Boiling point:
- 711.0±70.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 100mg/mL
- form
- Solid
- pka
- 17.48±0.30(Predicted)
- color
- Light brown to brown
N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine Usage And Synthesis
Description
AZA1 is a Rac1/Cdc42 GTPase-specific inhibitor which suppresses prostate cancer.
Uses
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[1][2].
in vivo
AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice and improving survival[1].
| Animal Model: | 5 week-old athymic nu/nu (nude) mice (bearing 22Rv1 prostate cancer cell xenografts)[1] |
| Dosage: | 100 μg in 100 μl 30% DMSO |
| Administration: | I.p.; daily for 2 weeks |
| Result: | The suppressive effect of AZA1 on tumor growth was significant. |
References
[1] Zins K, et al. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One. 2013;8(9):e74924. Published 2013 Sep 11. DOI:10.1371/journal.pone.0074924
[2] Suzuki O, et al. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47(6):2091‐2099. DOI:10.3892/ijo.2015.3211
N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamineSupplier
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