SR-717 Chemical Properties

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in DMSO (>25 mg/ml)

form 

solid

color 

Off-white

Water Solubility 

Water: < 0.1 mg/mL (insoluble)

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.

SR-717 Usage And Synthesis

Description

SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 μM).? It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.

References

Chin et al. (2020), Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic; Science 369 993

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