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PHENYL-P-BENZOQUINONE

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PHENYL-P-BENZOQUINONE Basic information

Product Name:
PHENYL-P-BENZOQUINONE
Synonyms:
  • 2-Phenyl-[1,4]benzoquinone
  • 2-Phenyl-1,4-benzoquinone
  • 2-phenyl-2,5-cyclohexadiene-1,4-dione
  • 2-Phenylbenzoquinone
  • 2-phenyl-p-benzoquinon
  • 4-dione,2-phenyl-5-cyclohexadiene-1
  • o-phenylbenzoquinone
  • p-Benzoquinone, 2-phenyl-
CAS:
363-03-1
MF:
C12H8O2
MW:
184.19
EINECS:
206-654-5
Mol File:
363-03-1.mol
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PHENYL-P-BENZOQUINONE Chemical Properties

Melting point:
111-115 °C
Boiling point:
278.14°C (rough estimate)
Density 
1.1336 (rough estimate)
refractive index 
1.6086 (estimate)
storage temp. 
2-8°C
form 
Chunks and Powder
color 
Yellow-brown
EPA Substance Registry System
2,5-Cyclohexadiene-1,4-dione, 2-phenyl- (363-03-1)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-42/43-20/21/22
Safety Statements 
37/39-26-36
RTECS 
DK6650000
HS Code 
29146990
Toxicity
dnd-rat-par 50 mg/L JJCREP78,1027,87

MSDS

  • Language:English Provider:ACROS
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PHENYL-P-BENZOQUINONE Usage And Synthesis

Chemical Properties

Yellow-brown chunks and powder

Uses

Phenylquinone is used for small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity whichrepresents a potential strategy for anticancer therapy.

Synthesis Reference(s)

Journal of the American Chemical Society, 118, p. 2509, 1996 DOI: 10.1021/ja954009q

Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes

Purification Methods

Crystallise the quinone from heptane, pet ether (b 60-70o), *C6H6 (m 113.5-114.5o) or EtOH (m 112-113o) and sublime it in vacuo. [Carlson & Miller J Am Chem Soc 107 479 1985, Beilstein 7 H 740, 7 III 3764.]

PHENYL-P-BENZOQUINONESupplier

J & K SCIENTIFIC LTD.
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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Shandong Xiya Chemical Co., Ltd
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Spectrum Chemical Manufacturing Corp.
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Thermo Fisher Scientific
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cnchemical@thermofisher.com