Althiazide Chemical Properties

Melting point:

206-207°

Boiling point:

625.8±65.0 °C(Predicted)

Density 

1.502±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Practically insoluble in water, soluble in methanol, practically insoluble in dichloromethane.

pka

8.33±0.40(Predicted)

color 

White to Off-White

EPA Substance Registry System

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-, 1,1-dioxide (5588-16-9)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Althiazide Usage And Synthesis

Description

Althiazide, also known as altizide, is an agent belonging to the class of thiazide diuretics with antihypertensive activity. This aldosterone antagonist is often combined with spironolactone.

Chemical Properties

White Solid

Originator

Althiazide,Solchem

Uses

Diuretic and antihypertensive.

Definition

ChEBI: Althiazide is a benzothiadiazine. It is the thiazide and sulfonamide derivative.

Manufacturing Process

To 6.75 g (0.0225 mole) of 4-amino-2-chloro-5-(methylsulfamyl) benzenesulfonamide in 45 ml of dimethylformamide is added 4.86 g (0.03 mole) of dimethyl allylmercaptoacetal followed by 1.5 ml ethyl acetate saturated with hydrogen chloride gas. The solution is refluxed for 1.5 hours, cooled and added dropwise with stirring to ice/water. The resulting precipitate is filtered, dried and recrystallized from isopropanol. The recrystallization gave 4.0 g of 2-methyl-3-allylthiomethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide; M.P. 168.5-170°C.

Therapeutic Function

Diuretic, Antihypertensive

Althiazide(5588-16-9)Related Product Information

• o-Chlorobenzenesulfonamide
• Benzenesulfonamide, 2-(methylamino)- (9CI)
• 4-Chloro-N-methylbenzenesulphonamide
• Althiazide
• Hydrochlorothiazide
• 2-Aminobenzenesulfonamide
• 4-Chlorobenzenesulfonamide
• CLOFENAMIDE
• 4-Amino-6-chlorobenzene-1,3-disulfonamide
• Methalthiazide
• 2-AMINO-N-METHYLBENZENESULFONAMIDE
• 4-CHLORO-1,3-BENZENEDITHIOL