Methoxyacetonitrile Chemical Properties

Melting point:

97 °C

Boiling point:

118-119 °C/731 mmHg (lit.)

Density 

0.956 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.381(lit.)

Flash point:

89 °F

storage temp. 

2-8°C

Water Solubility 

Insoluble in water

solubility 

soluble in Chloroform, Ethyl Acetate

form 

Liquid

color 

Clear colorless to yellow

BRN 

1738014

CAS DataBase Reference

1738-36-9(CAS DataBase Reference)

NIST Chemistry Reference

Methoxyacetonitrile(1738-36-9)

EPA Substance Registry System

Acetonitrile, methoxy- (1738-36-9)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

10-20/21/22

Safety Statements 

14-36/37

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

HazardClass 

3.2

PackingGroup 

III

HS Code 

29269090

MSDS

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Methoxyacetonitrile Usage And Synthesis

Chemical Properties

Colorless to light yellow liquid

Uses

2-Methoxyacetonitrile, is used as a building block in various chemical synthesis. It can be used for the synthesis of substituted isoquinolines and biisoquinolines for use in the construction of heterocyclic compounds.

Application

Methoxyacetonitrile is a protected formaldehyde equivalent that undergoes metalation and addition with a variety of electrophiles and intercepts a variety of nucleophiles at the cyano group.

Preparation

Methoxyacetonitrile is prepared from Formaldehyde, Sodium Cyanide, and Dimethyl Sulfate.

Methoxyacetonitrile(1738-36-9)Related Product Information

• 4-Methoxybenzyl cyanide
• p-Anisidine
• 4-Methoxyphenol
• (Trifluoromethoxy)benzene
• p-Anisaldehyde
• POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE
• Anisole
• Guaiacol
• Amygdalin
• Ethyl cyanoformate
• LINAMARIN
• 3-CHLOROPHENOXYACETONITRILE
• 2-(2,4-DICHLOROPHENOXY)ACETONITRILE
• BENZYL CYANOFORMATE
• Methyl cyanoformate
• PRUNASIN
• 2-CHLOROPHENOXYACETONITRILE
• 4-METHOXYPHENOXYACETONITRILE