2-Amino-6-chlorobenzoic acid Chemical Properties

Melting point:

158-160 °C (lit.)

Boiling point:

250°C (rough estimate)

Density 

1.3246 (rough estimate)

refractive index 

1.5560 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Crystalline Powder

pka

0.97±0.10(Predicted)

color 

Light yellow to beige

Water Solubility 

Very soluble in water. Soluble in methanol.

BRN 

2804041

InChIKey

SZCPTRGBOVXVCA-UHFFFAOYSA-N

CAS DataBase Reference

2148-56-3(CAS DataBase Reference)

NIST Chemistry Reference

2-Amino-6-chlorobenzoic acid(2148-56-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29224999

MSDS

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2-Amino-6-chlorobenzoic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-6-chlorobenzoic acid is used as intermediate for medicine.

Application

The tricyclohexyltin 2-amino-6-chlorobenzoate was synthesized by the reaction of the tricyclohexyltin hydroxide with the 2-amino-6-chlorobenzoic acid.

Preparation

A, in the reaction vessel being provided with agitator, thermometer, reflux condenser, Dropping funnel, add cerium chloride 0.16mol, 4-hydroxy 3-methoxybenzene ethanol solution 0.19mol, Klorvess Liquid 400-500ml, control mixing speed and exist 160-190rpm, rising solution temperature, to 60-65°C, is slowly added to 2-chloro-6-nitrobenzoyl acid solution 0.13mol, sulfurous acid Hydrogen potassium solution 200ml, raises mixing speed to 260-310rpm, back flow reaction 5-7h；
B, reduction solution temperature, to 15-19°C, separate out solid, filter, and add diammonium hydrogen citrate solution 150-in filtrate 180ml, concentrating under reduced pressure, separate out solid, filter, dehydrant is dehydrated, brine, and pyridine solution washs, ethyl acetate solution Middle recrystallization, obtains crystal 2-amino-6-chlorobenzoic acid (C7H6ClNO2).

reaction suitability

reaction type: solution phase peptide synthesis

2-Amino-6-chlorobenzoic acid(2148-56-3)Related Product Information

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